ABSTRACT
Objective: To determinate that male fertility influenced by testicular volume in albino rats
Study Design: Experimental
Place and Duration of study: Institute of Basic Medical Sciences, Dow University of Health Sciences, Karachi, 10 months [November 2009 to August 2010]
Methodology: Sixty four adult albino rats were obtained from animal house Jinnah Postgraduate Medical Centre for the study and divided into 2 groups. Group A received injection normal saline 1 cc intraperitoneally [IP] daily for 8 weeks. Group B received lead chloride in a dose of 10 mg/kg body weight IP daily. On the day of completion of treatment the animals were sacrificed testes along with epididymis removed and place in Petri dish. The length, breath and width of testes were measured with help of vernier caliper. The spermatozoa were obtained from cauda epididymis
Results: The mean +/- SEM of volume testes in group A and B after eight week of treatment were 0.77142 +/- 0.04778 cm[3] and 0.11768 +/- 0.01673 cm[3] respectively. The volume of testes of group B was significantly decreased as compare to group B [P = 0.000]. Mean +/- . The mean +/- SEM number of sperm cells million / ml in groups A and B after eight week of treatment was 7.65 +/- 186706.553 and 1.84 +/- 132792.770 respectively. Number of sperms in group B were significantly decreased as compared to group A [P = 0.000]
Conclusion: There was relationship between volume of testes and male fertility