Role of topical antibiotics in prophylaxis against endophthalmitis following intravitreal antibiotics

Objective: To compare the prophylactic use of antibiotic with placebo to prevent post intra-vitreal endophthalmitis and other complications

Methods: A prospective, cohort study was conducted at Ophthalmology Department, Fauji Foundation Hospital [FFH], from June 2016 to July 2017. A total of 1082 eyes of 673 patients were enrolled in this study. Patients were selected at non-random and divided into two groups. In Group-I, non - exposed, placebo eye drops were given after intravitreal bevacizumab injections and in Group-II, exposed, ofloxacin eye drops were given after intravitreal bevacizumab injections

Results: Total 1082 eyes were given intravitreal bevacizumab injection in 673 patients. No patients in Group-I, non - exposed, receiving placebo eye drops developed post intra vitreal endophthalmitis, whereas only 01 [0.1 percent] patient developed post intravitreal endophthalmitis in Group-II, exposed, receiving ofloxacin eye drops. In inferential statistics the P- value was also statistically insignificant [x2 [1, N=1082] =0.95, P>0.05]

Conclusion: This study showed that topical antibiotic, as a prophylaxis after intravitreal injections has no role in the prevention of post intravitreal endophthalmitis and other complications

Outcome of pars plana vitrectomy with silicon oil versus scleral buckling in primary retinal reattachment surgery

To evaluate the outcome of primary pars plana vitrectomy with silicon oil tamponade versus scleral buckling procedureas a treatment for rhegmatogenous retinal detachment. This prospective, comparative, interventional study was conducted from July 2008 to June 2009. Patients were selected and divided into two groups. Pars plana vitrectomy [group I] or scleral buckling [group II] was performed as primary procedure. Patients were followed for 06 months after surgery. Anatomical outcome in pars plana vitrectomy procedure was 96.2% as compared to scleral buckling procedure 87.0%. Functional outcome in pars planavitrectomy, best corrected visual acuity of 6/6 - 6/18 was attained in 34.6%, in sclera buckling procedure 65.2% at 06 months. Anatomical outcome in pars plana vitrectomy is better as compared to sclera buckling. Visual outcome and visual rehabilitation is earlier and better in scleral buckling as compared to pars plana vitrectomy