ABSTRACT
The pandemic of metabolic disorders is accelerating in the urbanized world posing huge burden to health and economy. The key pioneer to most of the metabolic disorders is Diabetes Mellitus. A newly discovered form of diabetes is Maturity Onset Diabetes of the Young [MODY]. MODY is a monogenic form of diabetes. It is inherited as autosomal dominant disorder. Till to date 11 different MODY genes have been reported. This study aims to discover subgroups from the biological text documents related to these genes in public domain database. The data set was obtained from PubMed. Period: September-December, 2011. APRIORI-SD subgroup discovery algorithm is used for the task of discovering subgroups. A well known association rule learning algorithm APRIORI is first modified into classification rule learning algorithm APRIORI-C. APRIORI-C algorithm generates the rule from the discretized dataset with the minimum support set to 0.42% with no confidence threshold. Total 580 rules are generated at the given support. APRIOIR-C is further modified by making adaptation into APRIORI-SD. Experimental results demonstrate that APRIORI discovers the substantially smaller rule sets; each rule has higher support and significance. The rules that are obtained by APRIORI-C are ordered by weighted relative accuracy. Only first 66 rules are ordered as they cover the relation between all the 11 MODY genes with each other. These 66 rules are further organized into 11 different subgroups. The evaluation of obtained results from literature shows that APRIORI-SD is a competitive subgroup discovery algorithm. All the association among genes proved to be true
ABSTRACT
Dry suspension is commercial dry mixtures that require addition of water at the time of dispensing. The major consequence of the bitter taste is to restrict greatly the further development of oral preparations and clinical applications of these drugs. People wish to take effective drugs that have a nice taste can be administered easily. Accordingly, it is important to mask the unpalatable taste of a drug in order to improve the product quality. The solvent evaporation process is used for microencapsulation which is carried out in a liquid manufacturing vehicle. Eudragit L100 is used as taste masking agent. FT-IR study shows that there is no significant interactions occurring between drug and excipients. The suspension prepared was evaluated for various parameters like sedimentation volume, degree of flocculation, drug content and In-vitro dissolution time. All the parameters were found to be within limits. When the results were compared with marketed preparation suspension was found to be better with respect to marketed preparation.