ABSTRACT
To evaluate the effect of combination of Nigella sativa and Trigonella foenum-graecum seeds with Glibenclamide on blood sugar levels in type-2 diabetes mellitus patients. Arandomized clinical trial. Diabetic outpatient clinics of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Jamshoro, Pakistan from March to August 2008. For this study, Type-2 diabetic mellitus patients on Glibenclamide, who gave written consent to volunteer in the study, were randomly divided into two groups. Fifty patients in Group [A] [Control Group] remained on routine dose of Glibenclamide, while fifty patients in Group [B] [Intervention Group] were kept on a capsule containing combined powder of N-sativa and T. foenum-graecum seeds powder, in addition to their routine dose of Glibenclamide. Patients in both the groups were evaluated for a period of 3 months for fasting and random sugar levels. It was found that the blood sugar level fasting [p-value=0.003] and the random [p-value<0.001] significantly decreased in intervention group compared to control group. This study indicates that combination therapy of N. sativa and T. foenum-graecum seeds with Glibenclamide has significant effect in controlling hyperglycemia