ABSTRACT
Replacement of aortic valve with the pulmonary autograft is carried out through the Ross procedure due to its potential for growth, durability in pediatric population, and absence of anticoagulation. This case series reports the postoperative outcome of two technical variations of Ross procedure in eight patients who underwent surgery from January 2007 to December 2016. The dominant valvular hemodynamic indication was aortic regurgitation. The techniques employed for Ross procedure included free standing root replacement in six patients and modified root replacement with autograft stabilisation using Dacron interposition graft in two patients. Right ventricular outflow tract [RVOT] conduit reconstruction was achieved by utilisation of Contegra bio prosthesis in four patients; and use of manually constructed valved conduit comprising of PTFE [polytetrafluoroethelene] membrane and bovine pericardial tube in remaining four patients. There was no mortality and no re-intervention. The technical varieties of Ross procedure offer freedom from need of anti-coagulation, mortality, and RVOT conduit failure in younger adults
ABSTRACT
The exact mechanism of otoneurotoxicity of gentamicin is unknown. A study was carried out on the auditory cortex of rat brain both 'in vitro' and 'in vivo' following the administration of gentamicin 135 mglkg body weight for 21 days. Interestingly, the Mg2+ dependent ATPase was increased following the intoxication of gentamicin