ABSTRACT
Background: Idiopathic thrombocytopenic purpura [ITP] is a rare autoimmune disease characterized by the platelet destruction that is autoantibody mediated, and there is suboptimal platelet production in the absence of a known cause, this leads to decreased peripheral blood platelet counts or thrombocytopenia and Helicobacter pylori has direct association with ITP. The aim of this study was to see the platelet recovery in patients of ITP after the H. pylori infection eradication
Methods: This was a case control study and 120 ITP patients who tested positive for H. pylori [divided into age and sex matched treatment and the control groups] were enrolled from the outdoor patients [OPD] of Sheikh Zayed Medical Complex. Stool antigen [HpSA] enzyme immunoassay method [EIA] method was used for H. pylori detection
Results: The response of the platelet count in the treatment group was a 'complete response' in 35 [60.3%] patients, a partial response in 16 [27.6%] patients and no response was found in 7 [12.1%] cases. However, no remarkable change was seen in the platelet counts of the patients in the control group
Conclusion: Complete eradication of H. pylori helps in the recovery of H. pylori induced platelet reduction and detection and eradication of H. pylori infection should be considered in the work-up of patients with ITP
ABSTRACT
This study tried to find out the physiological risk factors as well as biochemical factors in a group of Pakistani peri- and postmenopausal women. One hundred female subjects with age range of 40-52 years were included in the study. Female subjects were divided into two groups, i.e., 65 women with perimenopausal status age range 40- 52 years old and 35 women with post menopausal status age range of 50-60 years. Detailed histories of subjects including factors that may contribute in bone fracture were recorded. Bone density was scanned. Blood parameters like serum calcium, alkaline phosphatase, total protein and uric acid were estimated. It was found that 70% of perimenopausal women belonging to class B were physically active. Hormonal replacement therapy [HRT] was observed in 25-30% of both groups. On the other, only 15% of both groups used oral contraceptives. Family history was found to be only in 10% of both groups. Level of serum calcium of perimenopausal/postmenopausal was less than normal control subject. Although the level of alkaline phosphatase was increased in perimenopausal women as compared to postmenopausal women and normal control subjects. Bone density of both peri- and postmenopausal women significantly decreased as compared to T score of normal control. It was concluded that a number of factors are predictive of future risk for the development of osteoporosis in women of reproductive age. Given the severity of the medical consequences of osteoporosis, the medical community needs to assess all women for these risk factors during their perimenopausal years