Single oral dose fluconazole therapy in vaginal candidiasis

Fluconazole in a single oral 150 mg capsule was used to treat thirty adult non pregnant women proved to have positive vaginal cultures for candidiasis. Pruritus, discharge, and burning were the monitoring symptoms of the efficacy of therapy. Patients were seen at 3 visits; visit 1 before treatment, visit 2 [7-14 days after treatment] and visit 3 [30-45 days after treatment]. Criteria of cure were based on clinical and mycological results. At visit 2, pruritus and burning remained only in 3 and 2 patients respectively, while discharge was present in 9 cases showed positive vaginal culture [only 5 of them were symptomatic]. These five symptomatic cases, repeated the same treatment. 4 of them showed negative culture during the third visit one remains positive. Clinical tolerability to Fluconazole therapy was excellent in 29 cases while on case complained of transient vomiting. No significant were induced on blood picture, liver and renal function tests after therapy

Correlation between toxoplasma IgG seropositivity and history of spontaneous abortion or stillbirth

This study was conducted on 90 women aged 16- 41 years who attended the obstetric and gynaecologic unit at Kasr-El-Aini Hospital, Cairo University. Fifty of them were pregnant in their third trimester and 40 were non pregnant controls. Their sera were tested for the presence of IgG toxoplasma antibodies using IFA test. Cord blood from pregnant women at delivery was also tested. IgG positive cord blood was tested for IgM toxo-antibodies. Of 90 women 19 [21+ACU-] were seropositive for IgG toxo antibodies. There was no significant difference in seropositivity by age group. Of 33 women with history of spontaneous abortion 11 [33+ACU-] were seropositive as compared to 8 [14+ACU-] of 57 who had not [P less than 0.05] with no correlation between positive toxoplasma serologic status and status and stillbirth. Eleven of 50 pregnant women were IgG toxo antibodies positive. All gave birth to babies with IgG toxo antibodies and the titers for mothers and offsprings were comparable. All cord blood samples were negative for IgM toxo antibodies

Intramuscular sulbactam/ampicillin combination therapy in gynecological and obstetrical bacterial infections

Clinical and bacteriological assessment of efficacy of intramuscular sulbactam / ampicillin combination, together with assessment of its toleration and safety in the treatment of gynecological and obstetrical infections were carried out thirty adult females with pelvic inflammatory disease, wound infections, vaginitis and puerperal sepsis received intramuscular sulbactam / ampicillin combination in a total daily dose of 1.5 gm. The duration of therapy ranged between 3 and 7 days. Clinical cure and improvement were achieved in 27 cases [90%] and no response was seen in 3 cases [10%]. No side effects were seen in 29 cases [96.7%], while tolerable local injection site pain was reported in 1 case. The safety of the sulbactam / ampicillin antibiotic combination was quite evident in all the studied cases through the absence of significant differences in the means of laboratory tests done before and after therapy on haemogram and renal functions