Undescended testis: early forecasting cases candidate for surgery

To correlate the age of presentation primary site as well as pretreatment hormonal profile with the outcome of hormonal treatment would help to predict early the non-responders and hence offer them surgery from the start. We analysed 65 boys with undescended testes, 22 bilateral and 43 unilateral, their age range 3-12 years [6.5 +/- 1.2]. All of them were subjected to hormonal profile estimation [FSH, LH, testosterone and IGF-I] and sonographic evaluation for accurate localization of testes. Cases where there ivas failure to visualize testes were excluded from the study. We have found that 20 testes were high scrotal, 42 inguinal and the remainder [25] were located in the abdomen. Hormonal therapy [HCG] was given to all cases and the sonographic progress of testes was assessed 12 weeks after treatment. Thirty two testes moved distally with therapy [4 bilateral and 28 unilateral]. Discriminant equation shoivs 95% accuracy with the age and primary site being the most important predictors. We can conclude that the best the results of hormonal treatment are obtained the earlier the treatment is started and in the most distally located undescended testes

Decreased serum levels of insulin - like growth factor - 1 [I G F - 1] and insulin - like growth factor binding protein - 3 [I G F B P - 3] in children with underscended testes

This study was carried out on 65 boys with undescended testes [22 bilateral and 43 unilateral] in comparison with 20 apparently healthy normal controls of a matched age. All of them were subjected to hormonal estimation follicle stimulating hormone [FSH], LH, growth hormone [GH], testosterone in addition to IGF-1 and IGFBP-3 and sonographic evaluation for an accurate localization of testes. The serum levels of FSH, LH and GH were determined using solid phase, two- site chemiluminescent enzyme immunometric assay. Total testosterone was measured by the electrochemiluminescence immunoassay. Free testosterone and IGFBP-3 were measured by radioimmunoassay technique, while IGF-1 was measured by active non-extraction ELISA technique

incidence of crystals deposition in inflammatory osteoarthritis

The present study was done to detect the incidence of Hydroxy apatite [HA] Calcium. Pyrophosphate Dihydrate [CPPD] and monosodium urate [MSU] crystals in synovial fluid of inflammatory Osteoarthritis [OA] by using alizarin red S stain and polarized light microscopy This study included 100 patients, 83 females [83%] and 17 males [17%] and their ages were ranged between 38-65 years with a mean of 45.9-1.3 years. HA was detected in 36% of cases, CPPD was detected in 30% of cases MSU was detected in 5% of cases while 55% of cases had no crystals in their synovial fluid. Also we found that there was coexistence between HA and CPPD crystals in 16 cases of those who had crystals in their synovial fluid [45 patients] and also the difference in the incidence between AH and CPPD crystals was statistically in-significant, while the difference between the incidence of HA and MSU as well as the difference between the incidence CPPD and MSU crystals was statistically significant. We concluded that alizarin red S staining is a rapid simple and sensitive technique helpful in detecting the presence of aptite crystals and that the concordance of HA and CPPD crystals might be of potential clinical and pathogenic significance