ABSTRACT
The purpose of this investigation was to evaluate the effectiveness of pretreatment with drug combination. The analgesic effect of the test drugs on rats was studied using Harvard Tail-flick apparatus. Albino rats, weighing 300-350 g were utilized for this study. The rats were divided into four groups. Group 1 received saline orally. Group 2 received 50 mg/kg paracetamol orally. Group 3 received 1 mg/kg phenergan orally. Group 4 received paracetamol and phenergan concomitantly. The animals were subjected to thermal pain stimulus from the apparatus at different time intervals, after drug administration. The analgesic effect was estimated by the duration in seconds evoked until the reflex response occurred due to the thermal stimulation. Results showed potent analgesic effect in the rats pretreated with combination of paracetamol and phenergan compared with those which received paracetamol alone. Phenergan did not show significant analgesic effect. New methodology for pain assessment was established
Subject(s)
Surgery, Oral , Acetaminophen , Hypnotics and Sedatives , AnalgesicsABSTRACT
Osteoporosis may represent a problem for oral surgeon because of jaw bone fractures that may occur during the clinical course of the disease. However, in literature only very scant experimental studies were carried to investigate the disease. Animal model is needed to perform studying experiments to approach the currently unanswered research questions about osteoporosis. The author was able to induce, probably for the first time in the literature, osteoporosis in the jaw of the rat. This was accomplished by injecting the rat with 0.32 of dexamethasone intramuscularly, twice weekly for a period of 16 weeks. It is felt that this represents a step forward towards more extensive studies aimed to provide a better understanding of the etiology, nature of the disease and its treatment
Subject(s)
RatsABSTRACT
The purpose of this study was to evaluate the histopathological changes that can occur in skeletal muscle injected with a local anesthetic and steroid combination. The injection procedure was performed into the right gastrocnemius muscle of albino rats. The rats were divided into six groups: Group 1 [received 1 mg procaine], group 2 [received 1 mg procaine and 0.1mg Kenacort], group 3 [received 0.5 mg bupivacaine], group 4 [received 0.5 mg bupivacaine and 0.1 mg Kenacort], group 5 [received 0.1 mg Kenacort], group 6 [received 0.9% saline, as a control]. The study strongly suggested that bupivacaine has the potential to be more toxic to skeletal muscle than procaine. In addition, it documented that the addition of steroid to the local anesthetic intensifies its myotoxicity; a situation of potential clinical importance
Subject(s)
Drug EvaluationABSTRACT
Bilharziasis was experimentally induced in Swiss albino mice in order to study the histopathological changes in the TMJ in case of bilharzial infection. The bony components of the joint showed massive chronic inflammatory cell infiltration. The articular disk [meniscus] showed thickening and hyperplastic changes with narrowing of the joint space. The articulating surfaces showed erosions and irregularity. It was concluded that bilharziasis can cause arthropathy of the temporomandibular joint [TMJ]
Subject(s)
Schistosomiasis/pathologyABSTRACT
The significance of condylar position in TMJ dysfunction-pain syndrome is still disputed. Transcranial radiographs were performed in 30 symptomatic TMJs [15 subjects] and compared with those performed in subjects without symptoms. Of the condyles in symptomatic subjects, 77% had posterior displacement. Of the condyles in asymptomatic subjects, 43% had posterior displacement. In addition, the incidence of condylar asymmetry was statistically significant in the symptomatic group. It appears that condylar position in the fossa is of great significance in TMJ dysfunction-pain syndrome