ABSTRACT
The antibody response after vaccination by reduced regimen of plasma derived hepatitis B vaccine (Hevac B) was studied. The vaccines were 48 medical student, who were seronegative for HBV markers. The vaccination schedule was at 0, 1 and 6 months, whereas the recommended schedule for this vaccine is at 0, 1, 2, 12 months. Anti-HBs and anti-HBc were measured at 1, 2, 7 months after the first dose. The seroconversion rate of anti-HBs were 14.9, 62.2, 84.6% and GMT (geometric mean titer) were 24.3, 128.4, 8037.3 mlU/ml respectively. No serious side effect was recorded. Six vaccines, who were seronegative after the third dose of vaccination, received another additional dose at 1 year after first dose. Blood testing performed 1 month after such booster dose showed seroconversion in 5 of 6 vaccinees.