ABSTRACT
Background: Early diagnosis of mycosis fungoides is essential but difficult and can be easily missed because it mimics many inflammatory skin diseases both clinically and histopathologically
Objective: To analyze the clinical and pathological features of mycosis fungoides. Design: A Retrospective Study
Setting: King Hussein Medical Center, Jordan University Hospital, Al-Karak Governmental Teaching Hospital
Method: All patients diagnosed with mycosis fungoides from 2000 to 2015 were included in the study. The patients' clinical data were retrieved. The histopathological findings were interpreted by a dermatopathologist. Hematoxylin and Eosin routine stain was used for histopathological interpretation. Immunophenotyping stain was performed for few cases; T-cell rearrangement was not performed
Result: Sixty-three patients diagnosed with mycosis fungoides were included in this study; 43 were males and 20 females. Male to female ratio was 2.15:1. Age ranged from 11-80 years; the mean age was 45 years. The lesions involved the trunk and proximal extremities in the majority of the cases. Different clinical variants of mycosis fungoides were seen in the patients: 25 [39.6%] classical mycosis fungoides, 7 [11%] hypopigmented mycosis fungoides, 2 [3.1%] hyperpigmented mycosis fungoides, 6 [9.5%] poikilodermatous mycosis fungoides, 1 [1.6%] folliculotropic mycosis fungoides, 1 [1.6%] erythrodermic mycosis fungoides, 1 [1.6%] ichthyosiform mycosis fungoides and 1 [1.6%] purpuric mycosis fungoides.
Conclusion: Mycosis fungoides can mimic different inflammatory skin diseases. However, early proper skin biopsy could be helpful for early diagnosis
ABSTRACT
To evaluate our experience in primary cutaneous malignant melanoma at King Hussein Medical Center which is a main tertiary care teaching hospital in Jordan, in order to determine the early recognition and diagnosis to give a better chance for treatment and a better prognosis and survival rate. Twenty four cases of primary cutaneous malignant melanoma, 14 males and 10 females, have been diagnosed at King Hussein Medical Center during the period January 2001 - May 2005 were included in this study. The histopathology records of these cases were reviewed and analyzed in accordance to their clinical data. Out of the 24 cases of cutaneous malignant melanoma, 14 males and 10 females with age range 15 years to 85 years old, and the mean age of [49] years for females, and [57] years for males with skin type [II-IV]. There were only four cases that have been diagnosed at early stage with Clark level I, and II, and III. The rest of 20 cases were Clark level IV and V. There were nine cases out of the 20 who had metastases at the time of diagnosis. In this study, we noticed that most of malignant melanoma cases were not diagnosed at their early treatable and curable stage. So we need to improve public and physician awareness of this highly malignant yet visible tumor and also advise people for self skin examination to detect any pigmented lesions that look unusual. Skin biopsy is essential for the diagnosis of melanoma for any suspicious skin lesions