ABSTRACT
The aim of our study is to evaluate anatomic regeneration and metabolic derangement of the liver after major resection in dogs This is an experimental study on 9 dogs; we divided the dogs in two groups: the first group [5 dogs] underwent at one go major hepatectomy [90% of the liver].The second group [4 dogs] underwent successively a resection of 75% of the liver and a second resection of 90% of the restored liver six months later. All dogs underwent a metabolic and morphologic studies of the liver and of their kidney function In the first group; all dogs which underwent 90% hepatic resection died 48 hours after the surgical resection of hepatic insufficiency. The ultra microscopic study shoud the role of portal hypertension in hepatic degeneration on the first group. In the second group, the dogs survived the first resection, and our study shows a regeneration of the liver after resection and sub normal hepatic function The liver is able to regenerate after minimall resection but major resection must be done by successively resection to avoid hepatic dysfunction, but the time between resection must be evaluate later