histo-pathology of human Giardiasis

This study was carried out on a sample of 1240 adult persons. In giardiasis symptomatic group [I], the prevalence of diarrhea was 71.43%, 100% in grade 0, I, II, III and IV pathology, respectively, which was statistically insignificant in comparison with each other. The prevalence of abdominal pain was 71.43%, 73.33%, 95%, 91.67% and 100% in grade 0, I, II, III and IV pathology, respectively, which was statistically insignificant compared with each other. The prevalence of flatulence was 42.86%, 40%, 80%, 83. 33% and 100% in grade 0, I, II, III and IV pathology, respectively, which was statistically significant in comparison with each other. So, the prevalence of flatulence was more frequent in patients with marked pathological changes in the duodenum. The prevalence of anorexia was 14.29%, 53.33%, 65%, 50% and 100% in grade 0, I, II, III and IV pathology, respectively, which was statistically significant in comparison with each other. The prevalence of vomiting was 0%, 13.33%, 15%, 16.67% and 85.71% in grade 0, I, II, III and IV pathology, respectively, which was significantly increased in grade IV and disappeared in grade 0

Evaluation of two serological tests in diagnosis of human cases of biliary and ectopic fascioliasis

In the present study, sera were examined using Fasciola-IHA, F-ELISA and Schistosoma-IHA. The seropositive schistosomal patients were subjected to rectal snip, while the seropositive fascioliasis ones were examined radiologically by plain chest X-ray and abdominal ultrasonography. Both F-IHA and F-ELISA gave 100% sensitivity. The specificity of both tests was 90.4% and 100%, respectively. With the S-IHA, the parasitologically proven schistosomal mansoni patients gave 95% positivity; while, the proven fascioliasis patients gave false positivity [8%] with this S-IHA. The radiological findings of the fascioliasis patients confirmed ectopic pleuropulmonary infection in five patients. Ascitis was detected in one patient. The pleural effusion and ascitic fluids showed high eosinophils. However, Fasciola eggs were detected in three patients only. Two patients showed hepatic nodules and another two had hepatic cystic lesions. Three patients had immature Fasciola worms in gall bladder. For the diagnosis of human fascioliasis, serological and radiological means should be done together with the stool examination. This is particularly true in chronic cases and in schistosomiasis mansoni endemic areas

effect of cyclosporine A [CSA] on murine visceral toxocariasis canis

Swiss mice experimentally infected with T. canis were treated by cyclosporin A [CSA]. The direct antiparasitic effect was noticed when administered on the same day of infection and was more effective when repeated for eight weeks. Although immunosuppression of CSA increased the susceptibility of mice to T. canis larvae, its direct antiparasitic effect was more effective and led to diminution of living T. canis larvae. Cellular immunity was inhibited as revealed by diminution of T. lymphocytes by decreased lymphocytes migration inhibition percentage on repeated administration of CSA for four weeks

profile of intestinal amebiasis in Dakahlia Governorate using the cellulose acetate precipitin test

Entamoeba histolytica is a highly endemic disease in Egypt. The present work was carried out to study the prevalence of amaebiasis in different population groups in Dakahlia province. Two hundred and one patients were examined, of them 110 were males and 97 were females of different age groups. The total infection rate, was found to be 27.3% and 31% among males and females respectively, while invasive amoebiasis were used including stool examination by the Merthiolate iodine formaldehyde concentration[MIFC] method, the indirect haemagglutination[IHA] and the cellulose acetate precipitation [CAP] tests. The IHA test was found to be more specific and sensitive while the CAP test was easier in the application and gave more qualitative information about invasive amoebiasis which favours its application in seroepidemiological studies