ABSTRACT
Nasogastric tubes [NGTs] are important for feeding, stenting and decompression after gastrointestinal surgeries, particularly in the upper gastrointestinal tract. Resistance in the removal of a NGT is a rare surgical complication and may be due to a knot in the tube or a stitch anchoring the tube to an anastomosis. We report a 41-year-old male patient who was admitted to the King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, in 2015 with stomach cancer. He underwent a radical total gastrectomy with a Roux-en-Y oesophagojejunostomy. One week after the surgery, removal of the NGT was attempted; however, this was very difficult and the proximal end of the tube was cut off as a temporary measure. Six weeks later, an upper gastrointestinal tract endoscopy revealed that the distal end of the NGT had been accidentally stitched to the Roux-en-Y oesophagojejunostomy. The stitch was removed and the rest of the NGT was successfully extracted using a snare
ABSTRACT
Background: HCC comes in the sixth rank in all tumors that influence the human body and it is generally connected with interminable liver cirrhosis in 80% of patients. In Egypt, the rate of HCC has expanded pointedly in the last decade. It is considered as a heterogeneous illness including variable types of neoplasms, which includes distinctive profile changes in both mRNA and miRNA expression. One of them is miRNA 483-5P which was found to be up-regulated in hepatocelleular carcinoma
Objectives: To assess the diagnostic and prognostic potential of circulating miRNA 483-5p in HCC in Egyptian patients in comparison to chronic liver disease patients and healthy controls
Methodology: This study was done on 100 HCC patients, 50 chronic liver disease [CLD] due to HCV infection and 50 healthy subjects. Serum alpha fetoprotein [AFP] was measured in all subjects by Chemiluminescence. The relative quantitation of miRNA 483-5p was determined by real-time quantitative Polymerase Chain Reaction [RT-qPCR]
Results: the results revealed an over expression of miRNA-483-5p in HCC group [p < 0.001] compared to both CLD and healthy subjects, while no significant change was detected between CLD and healthy subjects. MiRNA483-5p expression increased significantly with increased number of focal lesions and size of tumor. Receiver Operator of Characteristics [ROC] curve analysis of plasma miRNA-483-5p revealed that, at a cut-off value of 3. 22 [fold expression], the sensitivity and specificity for differentiation of HCC cases were 88.0% and 92.0%, respectively
Conclusion: Circulating miRNA483-5p can be used as an early diagnostic biomarker for detection of HCC
ABSTRACT
Incidence of malignant ovarian germ cell tumors [MOGCTs] in the Saudi Arabian population has not been studied before. Therefore, the primary objective of this study was to define the population-based incidence rates and histopathological types of MOGCTs in the Saudi Arabian population from 1999 to 2008. Our study showed that MOGCTs are a common type of ovarian tumors in the Saudi Arabian population, and the incidence rates and histopathological types are relatively comparable to the international populations with few differences.
Subject(s)
Humans , Male , Cryptorchidism/complications , Abdomen , Testicular Neoplasms , Tomography, X-Ray ComputedABSTRACT
The recipients of liver transplantation [LT] are subjected to lifelong immunosuppression with its many drawbacks. De novo and recurrent malignancy in transplant recipients are attributed to attenuation of immunosurveillance. In the present study, we present our experience with de novo malignancies encountered after both deceased and living donor liver transplantations. Retrospective study of patients referred to LT center between April 2001 and January 2010. Various data were collected including type of malignancy and histopathologic features, immunosuppression regimen, and patient survival. Of 248 LT procedures performed in 238 patients [10 retransplants], 8 patients [3.4%] developed de novo post-LT malignancies. De novo malignancies included post-LT lymphoproliferative disorders [PTLD] in 5 patients who were all Epstein-Barr virus [EBV] positive, and who were treated successfully with anti-CD20 monoclonal antibody therapy, reduction of immunosuppression, and control of EBV activity; urinary bladder cancer in 1 patient who was treated with radical surgical resection and chemotherapy but died of bone and lung metastasis within 1 year of diagnosis; endometrial carcinoma in 1 patient who was treated with radical surgical resection; and Kaposi sarcoma in 1 patient who was successfully treated with surgical excision and reduction of immunosuppression. EBV-associated PTLD is the most frequently encountered de novo malignancy after LT and is easily treatable by chemotherapy and reduction of immunosuppression
ABSTRACT
Living donor liver transplantation [LDLT] has been expanding to adult recipients by using right lobe grafts. However, the incidence of complications is more frequent than that involving left lobe grafts. Hence, we aimed to analyze postoperative complications in right lobe liver donors as a step to improve the results in the donors. Three hundred and eleven right lobe liver donors were retrospectively reviewed between February 1998 and December 2003. The ages of the donors ranged from 19 to 64 years [median: 46 years]. Their body mass index ranged from 16.6 to 34.3 [median: 22.1]. The mean duration of the operation was 6.58 [1.25] hours and blood loss was 289 [254] mL. The estimated median donor residual liver volume was 42.2% [range: 20.6-60.3%] and the median hospital stay was 14.5 days [range: 6-267 days]. One donor died of liver failure due to small residual liver volume [26%] and steatohepatitis. One hundred and twenty three complications occurred in 104 donors [33.4%]. Donors experienced one or more complications. According to the Clavien classification, grade I complications occurred in 71 of the episodes [57.7%], grade II complications in 9 [7.3%], grade IIIa complications in 39 [31.7%], grade IIIb complications in 3 [2.5%], and grade V complications in 1 [0.8%]. Biliary complications were the most common and occurred in 37 donors [12%]. Right lobe liver donation is a widely accepted procedure that results in the expansion of the indication for LDLT to adults and large children. However, remnant liver size and anatomical variations in the biliary tree represent important risk factors for postoperative complications