Prevalence and significance of cytogenetic findings of acute lymphoblastic leukemia: experience at king Hussein medical center

To determine the spectrum of cytogenetic abnormalities of acute lymphoblastic leukemia in children and adults at King Hussein Medical Center. A retrospective review of raw bone marrow aspirate cytogenetic analysis reports was conducted at Princess Iman Research and Laboratory Sciences Center at King Hussein Medical Center during the period between Jan 2010 and Apr 2014. A total of 97 patients were studied regarding: age, gender, and cytogenetic analysis. The age was categorized into two groups [14 years as adult group]. Descriptive analysis using frequencies was used to describe the study variables. Fifty-two [53.6%] cases were males and 45 [46.4%] were females. Their ages ranged between six months and 72 years. A total of 72 [74.2%] patients were children and 25 [25.8%] patients were > 14 years old. Of all pediatric acute lymphoblastic leukemia cases, 52.8% [38 cases] were negative for all the cytogenetic abnormalities, while 47.2% [34 cases] revealed one or more cytogenetic abnormalities. Translocation t[12;21], hyperdiploidy [>50 chromosomes or DNA index >1.16] were the predominant cytogenetic abnormalities in children with lymphoblastic leukemia. In the adult lymphoblastic leukemia group, 68.0% [17 cases] were negative for all the cytogenetic abnormalities, while 32% [8 cases] had cytogenetic abnormalities. Hyperdiploidy was the most common [20.0%, 5 patients] followed by translocation t [9;22] [8.0%, 2 patients]. Distribution and patterns of chromosomal abnormalities of lymphoblastic leukemia differ between children and adults. Translocation t[12;21], hyperdiploidy and rearrangements / translocations involving the MLL gene at chromosome 11q23 were the most commonly encountered in children. Hyperdiploidy was prevalent in adults, while no adult cases with 11q23 rearrangements or t[12;21] were encountered

Acute leukemia at King Hussein Medical Center: a retrospective review

To describe certain characteristics of acute leukemia regarding age, gender, cytomorphology and immunophenotype at King Hussein Medical Center. A retrospective review of bone marrow aspirate and/or biopsy reports was conducted at Princess Iman Research and Laboratory Sciences Center at King Hussein Medical Center during the period between Jan 2004 and Dec 2008. A total of 226 patients were studied regarding: age, gender, and cytomorphologic and immunophenotypic diagnosis. The age was categorized into two groups [14 years as adult group]. Descriptive analysis using frequencies was used to describe the study variables. This study was conducted to study and analyze acute leukemia cases in children and adults in King Hussein Medical Center over the past five years. One hundred thirty-eight [61%] cases were males and 88 [39%] were females. Their ages ranged between three months and 80 years. A total of 102 [45%] patients were children 14 years old. Acute lymphoblastic leukemia constituted 75% of all childhood leukemias, the majority [83%] were of B-cell phenotype mainly CD10+ve Precursor B-cell Acute lymphoblastic leukemia [74%]; only 17% of the childhood acute lymphoblastic leukemia was of T-cell phenotype. Acute myeloid leukemia constituted 80% of all adult leukemias; most of the cases were of the French-American-British M2 morphological subtype [34%]. Distribution and patterns of acute leukemia differs between children and adults. While CD10+ve Precursor B-cell acute lymphoblastic leukemia was predominant in children, acute myeloid leukemia M2 was prevalent in adults