ABSTRACT
This controlled experimental study was conducted to evaluate the effect of partial hepatectomy on enteric bacterial translocation in rats and the preventive action of dextran 70. Sixty rats were divided into three equal groups each of twenty animals. Animals in the first group [GI, n=20] were subjected to Sham operation, while 70% hepatectomy was done in the second group [GII, n=20] and third group [GIII, n=20] thirty minutes after saline and dextran 70 administration respectively. In each group, relaparotomy was done in 10 animals two hours and 12 hours postoperatively respectively during which inferior venacava [IVC] blood sample, intestine, mesenteric lymph nodes [MLN] and liver specimens were obtained for bacteriological examination. Detection of bacterial DNA in the IVC blood samples was also done using PCR- based technique. The results of this study revealed that partial hepatectomy induces significant intestinal bacterial overgrowth 2 hours [P <0.01] and 12 hours [P<0.001] postoperatively compared to Sham group. Also, bacterial translocation to MLN, liver and blood was noticed after partial hepatectomy compared to negative cultures in Sham operation. Dextran 70 injection significantly diminished enteric bacterial growth and translocation in partially hepatectomized rats .In conclusion, partial liver resection induces enteric bacterial translocation in rats that could be prevented by IV dextran 70 administration
ABSTRACT
Background: Appendectomy accounts for 1% of all surgical procedures. Laproscopic appendectomy has incited considerable controversy since its evolution. The purpose of this clinical study is to evaluate the results of some modifications added to the operation of laparoscopic appendectomy
Patients and Methods: Two groups of patients undergoing appendectomy were studied. In the first group 50 patients were subjected to open appendectomy. While the second group included another 50 patients whom were subjected to modified laparoscopic appendectomy. We compared the patients operative data, operative findings, postoperative complications, length of hospital stay and recovery variables
Results: Patients demographics, history of previous abdominal surgery and operative findings were similar in both groups. There were no intra or postoperative complications in the modified laparoscopic appendectomy group, due to the use of two 5 mm ports, ligation of the appendicular stump with ligatures, copious irrigation of the abdomen with saline and cleaning of the port sites with Povidone Iodine 10%
Conclusion: We conclude that with the new modifications added in our study, the incidence of postoperative complications were much lower than in other techniques. Also modified Iaparoscopic appendectomy offers considerable advantages primarily because of its ability for better scope of vision, good exploration, reduction of incidence of wound infection and its cost effectiveness