Modulation of acrylamide-induced oxidative damage in rat tissues by Curcuma longa L

Curcuma longa L. has shown to exert antioxidative, anti-inflammataory and anti-carcingoenic effects. Acrylamide [ACR] is neurotoxic to experimental animals and human. Also, it has mutragenic and carcinogenic effects. The present study was carried out to investigate the possible protective effect of Curcuma longa L powder on ACR-induced oxidative damage in rats. Twenty eight adult male Sprague Dawely albino rats were divided into four groups, each of 7 rats. Group 1 served as negative control and received the basal diet for 22 days. Group 2 [positive control] fed on basal diet for 22 days, starting 11 days later ACR was added to this diet [0.34g/kg diet]. The other two groups received the basal diet supplemented with, 250 and 500mg/kg diet Curcuma longa L powder for 22 days, starting 11 days later ACR was added to these diets [0.34g/kg]. Both tested doses of Curcuma Longa L powder significantly ameliorated ACR-increased levels of MDA and decreased levels and activities of reduced glutathione [GSH] and Cooper/Zinc superoxide dismutase [Cu/ZnSOD] enzyme in liver, testes and heart, Furthermore, treatment with Curcuma Longa L powder significantly restored the elevated activity of plasma aminotransferases [AST and ALT]; alkaline phosphatase [ALP] as well as the decreased levels of plasma total protein, albumin and globulin. The higher dose [500mg/kg diet] was more potent than the lower one. These findings indicated that ACR caused disturbance in antioxidants and liver enzyme activities, which in turn indicated organ damage during exposure to ACR. Curcuma longa L powder exhibited remarkable protection against these effects

Impact of social and nutritional factors on age of walking among infant and toddlers

Childhood is a transition from infancy to puberty ranging phase from the ages of one to three years. This phase is marked by several changes, with the growth and development peaked at the begging of this stage then soon take decreases gradually to become so little at the end. Childhood is divided in to three sections, early childhood from the age of 1-3 years old, preschool from 4-6 years and the school from 6-9 years .This study aims to: Identify of the social and economic of families on the basis of age at the beginning of the walking children. [And the Identification of health awareness for mothers the basis of age at the beginning of walking children]. the identification of physical measurement is anthropometric measurement were used as indicators of growth in relation to age at the beginning of walking. Examine the relationship between physical measurement of children and blood tests, as well as nutrition. This study was conducted on 310 children, aged 1 -3 years, they divided on the bases of age at the beginning of walking to 10 months, from 10 months to 12 months, and more than 12 months in a row, and to achieve the goals of the search were prepared form questionnaire for this purpose has been collecting data questionnaire from the mothers of children in Abd El azeziah hospital maternity and some health centers and dispensaries eligibility in Jeddah, has been used recurrences and percentages to explain the results, as was the use of, averages, standard deviation and variance analyses to determine the degree of relationship between some parameters used and age of children at the beginning of the age of walking

Alteration of oxidative status in rats following administration of acrylamide

Acrylamide [ACR] is a known industrial neurotoxic and carcinogenic chemical in rodents. The recent discovery of acrylamide in wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms. The present study is carried out to investigate the effect of acrylamide administration on in vivo malondialdehyde [MDA, a product of lipid peroxidation], reduced glutathione [GSH] as well as copper and zinc superoxide dismutase enzyme activity [Cu/Zn SOD] of rats. Fourteen adult male Sprague Dawley rats were divided into two groups each containing "7" rats. Group I served as negative control fed on basal diet and group 2 [positive control] received basal diet and acrylamide [0.34 g/ kg diet] for 11 days. Levels of MDA, GSH and activity of SOD were determined in liver, kidneys, brain, heart, testes, spleen and lungs of rats. ACR treatment significantly increased MDA in all organs; the highest increase was detected in testis [87.9%] and heart [71.5%] while the lowest one was found in kidneys [28.2%]. On the other hand, GSH levels and SOD activities were significantly reduced in ACR treated rats. However, the reduction of GSH level ranged from 10.2% to 36.5%.The inhibition of SOD activities were higher in testis [57.3%] and lungs [38.5%]. The present study showed that ACR exerts deteriorated effects on oxidative status of rats