ABSTRACT
Objective: To investigate the relationship between serum values of magnesium and the parameters of the pulmonary function tests [PFT] in patients with chronic asthma
Subjects and Methods: This study recruited 50 patients with chronic stable asthma and 40 healthy individuals as a control group. Data on age, sex, severity of asthma, PFT, and details of drug therapy were obtained from each group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were also measured. To evaluate differences between groups, the Student t test or Mann-Whitney U test was performed for continuous variables, and the X[2] test for categorical variables
Results: In the asthma group, 10% [n = 9] of the patients had hypomagnesemia and 5.5% [n = 5] had hypophosphatemia. Patients with asthma were divided into two groups: the hypomagnesemic group [n = 9] and the normomagnesemic group [n = 41]. Forced expiratory volume in 1 s [FEV[1]], FEV[1]%, peak expiratory flow [PEF], and PEF% were lower in the hypomagnesemic group than in the normomagnesemic group [p = 0.02]. Multiple logistic regression analysis revealed a statistically significant association between hypomagnesemia and PFT in the hypomagnesemic asthmatic group. The correlations of age with FEV[1], FEV[1]%, PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03, r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The correlation of serum magnesium levels with PFT [FEV1, FEV1%, PEF, PEF%] were as follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p = 0.001, r = 0.38, respectively. The other electrolytes were within the normal range in both groups
Conclusion: In this study, hypomagnesemia and hypophosphatemia were found to be the most common electrolyte abnormalities in patients with chronic stable asthma. FEV[1], FEV[1]%, PEF, and PEF% were significantly lower in asthmatic patients with hypomagnesemia compared to asthmatic patients with normomagnesemia
ABSTRACT
Recurrent thrombosis and lack of enough resolution of pulmonary emboli may lead to the development of chronic thromboembolic pulmonary hypertension. The purpose of this study was to investigate the correlation of initial, 10th-day and 6th-month lipid profile values with the changes in the pulmonary artery obstruction index in patients with pulmonary embolism [PE]
Twenty-eight patients diagnosed with PE were included in the study. Fifteen of them were treated using thrombolytic agents, and 13 of them were treated using conventional treatment. Pulmonary artery obstruction index of all patients was calculated after they underwent pulmonary computed tomography [CT] angiography. Arterial blood gas analysis and echocardiography were performed and lipid profile levels were analyzed during initial diagnosis and repeated on the 10th day and 6th month of the treatment
A significant positive correlation was found between HDL and percent change in pulmonary artery obstruction index. The patients with a high level of HDL showed better emboli resolution [P = 0.013]. Higher age and lower percent change in the 10th-day pulmonary artery obstruction showed a positive correlation with the persistence of embolism in the 6th month
Patients with lower HDL levels are at risk of recurrent embolic events and even chronic thromboembolic pulmonary hypertension, which can be prevented by HDL augmentation