ABSTRACT
Objective: To determine the relationship between biochemical recurrence and other histopathological factors in prostate cancer
Study Design: Analytical study
Place and Duration of Study: Pathology and Urology Departments, Izmir Ataturk Training and Research Hospital, between 2001 - 2013
Methodology: 117 cases diagnosed with prostatic adenocarcinoma and treated by radical prostatectomy were reviewed retrospectively for histopathological features; whereas, other prognostic findings were noted. PSA levels and many other histopathological parameters were assessed in order to put forth their effect on biochemical recurrence
Results: PSA level [p<0.001], tumor volume [p<0.001], Gleason score [p<0.001], extraprostatic extension [p<0.001], perineural invasion [p<0.001], ganglion involvement [p=0.040], vascular invasion [p<0.001], positive surgical margins [p<0.001], presence of tertiary pattern [p=0.004] and the involvement of the seminal vesicles [p<0.001] were found to be statistically related to the pathological stage. Age, perineural invasion, high grade tertiary pattern, intraluminal mucin, collagenous micronodules and foamy cytoplasmic changes were unrelated to recurrence
Conclusion: Histopathological features can be helpful in predicting prognosis in prostatic adenocarcinomas. However some of the histopathological factors such as intraluminal mucin and foamy cytoplasmic changes may not reflect high recurrence
Subject(s)
Humans , Male , Middle Aged , Aged , Aged, 80 and over , Recurrence , Adenocarcinoma , Biochemistry , Prostatectomy , Prostate-Specific Antigen , Neoplasm GradingABSTRACT
Parathyromatosis, in which several nodules of hyperfunctioning parathyroid tissue form in the neck and mediastinum, is a rare cause of recurrent hyperparathyroidism. However, there are some theories regarding the origin of parathyromatosis, and seeding after rupture of the parathyroid gland capsule during surgical removal of a parathyroid lesions is the most regarded one. Herein, we report a 41-year-old man who presented with multiple parathyroid nodules in and around the left thyroid lobe 5 years after parathyroid surgery for secondary hyperparathyroidism that was finally diagnosed as parathyromatosis. We discuss the differential diagnosis of parathyromatosis from other parathyroid tumors, particularly from parathyroid carcinoma, which is important in the management of a suspected lesion.