ABSTRACT
Objective: To measure the synergistic effects of Aloe vera and Rosiglitazone on blood glucose, insulin and insulin insensitivity in non-insulin dependent diabetes mellitus
Study Design: Randomized control trail study
Place and Duration of Study: This study was conducted at Army Medical College, Rawalpindi in the Physiology Department from January 2009 to September, 2010 in alliance with National Institute of Health [NIH] Islamabad
Materials and Methods: Thirty healthy rats were made diabetic according to Srinivasan model. After confirming type 2 diabetes in them they were randomly segregated into two equal groups. The groups named diabetic were injected with normal saline and other combined group were given 150mg/kg body weight of Aloe vera extract and 2.5mg/kg body weight of rosiglitazone diabetic group. It was half their effective dose as their effective dose was calculated through pilot study
Results: Plasma glucose, insulin, and TG/HDL ratio were significantly reduced [p<0.0000001] in combined group then diabetic control group
Conclusion: The significant result was obtained in combined group in lowering plasma glucose, insulin and insulin resistance though half their effective doses were used. It will also help in reducing side effects associated with use of rosiglitazone
ABSTRACT
Heerfordt-Waldenstr?m syndrome is also referred to as uveoparotid fever. In our patient physical examination showed bilateral parotid gland enlargement. Chest X-ray showed bilateral hilar lymph adenopathy. Biopsy specimen from the right parotid gland revealed scattered granulomas with focal central necrosis. Stains for acid-fast bacilli and fungi were negative. He was diagnosed as a case of Heerfordt- Waldenstr?m syndrome, a rare form of sarcoidosis in which the compression of the facial nerve results in palsy. He was treated with 60 mg of prednisone daily, and at follow-up after two weeks later, the swelling and uveitis was resolved