ABSTRACT
Enamel white spots are one of the patients' problems after fixed orthodontic treatment. Casein phosphopeptides [CPP] stabilize amorphous calcium phosphate. They may be used to reducing demineralization and enhancing remineralization. Topacal C-5 is one of CPP preparations.The purpose of this study was to evaluate the effect of Topacal C-5 on inhibition of further demineralization of enamel or remineralization of caries producing enamel lesions. In this study, 24 extracted human premolars were divided randomly in control and experimental groups. The samples were immersed in an artificial caries solution for an hour twice daily over a 31-day period. After each caries-producing attack, Topacal C-5 was applied on the exposed enamel window twice daily. Then, teeth were sectioned longitudinally and the depth of enamel lesion was measured under polarized light microscopy. A T-test and a T-paired test were employed to identify significant differences between the given groups [p<0.05]. The depth of the lesion in experimental group, was significantly lower than control group [p<0.05]. Topacal C-5 is a factor in reducing demineralization process or it may be effective in the induction of remineralization