ABSTRACT
Background and Objective: Finding the pain relieving substances is one of the important aims of biological researches. This study was done to evaluate the antinociceptive, anti-inflammatory effects of Hyssopus officinalis extract in mice
Methods: In this experimental study, 100 male adult mice were allocated into 5 experimental groups including control group receiving only normal saline and groups that received extract of Hyssopus officinalis at doses of 25, 50 and 75 mg/kg/bw, and positive control group in formalin test received morphine in acute and chronic phase of experiment and positive control group in anti-inflammatory test received dexamethasone. Formalin-induced paw licking was used to determine the antinociceptive activity of Hyssopus officinalis extract. The anti-inflammatory activity was determined by Xylene test
Results: In the acute phase of pain [the first 5 minutes], doses of 50 and 75 mg/kg/bw [7.75+/-2.3, 8.75+/-2.1] of the Hyssopus officinalis extract significantly reduced the number of feet raised [P<0.05]. Also, in the chronic phase of pain [20 min second], 25, 50 and 75 mg/kg/bw of doses [17.25+/-2.3, 11.75+/-2.9, 2.7+/-10.75] and morphine significantly reduced the duration of foot lift [P<0.05]. The extract of Hyssopus officinalis with three doses of 25, 50 and 75 mg/kg/bw [13.33+/-3.1, 20+/-3.1, 19.83+/-2.8] showed high anti-inflammatory activity against Xylene induced ear edema [P<0.05]
Conclusion: This study showed that Hyssopus officinalis extract can inhibit pain and inflammation in animal model