ABSTRACT
Diabetic foot ulcer is one of the most important chronic complication of diabetes, which led to prolonged hospitalization and finally amputation of the foot, has psychological and economic burden to individuals and families and the health system. Ischemia, Neuropathy and infection are three pathological factors which lead to diabetic foot complications. Although all diabetic foot ulceration are not preventable; physician knowledge, clinical examination of foot problems, treatment of small lesions, patient education and appropriate foot wear recommendation reduced the number of foot ulcer associated to diabetes. Components of basic concepts of the diabetic foot treatment including the infection control, establishing appropriate arterial blood flow and removing pressure and stress from painfuI areas [Offloading]. Along with standard treaments, there are supplementary therapies which accelerate the wound healing process such as novel dressings including hydrogel, Platelet-rich plasma [PRP], growth factors, stem cells, HBOT, VAC, and new herbal therapy [Angipars[TM]]. For compiling of current article, we have searched related sources through the databases of PubMed, Ovid, Google Scholar, Elsevier, UpToDate, Cohrane Library addition to printed journals in this field. It could be concluded that although various developments have been made in the field of diabetic foot ulcers has been made, most of them had the relative effects and complement each others; more effective treatments would be considered necessary