ABSTRACT
Background: the predictive roles of follicle stimulating hormone [FSH], anti-mullerian hormone [AMH] and antral follicle count [AFC] as ovarian reserve markers in women with different age groups are not established well
Objective: this study compares the value of FSH, AMH and AFC at the time of in vitro fertilization [IVF] treatment in different age groups
Materials and Methods: in this cross-sectional study, 103 women aged 20-43 years candidates for IVF/ICSI cycle were recruited. FSH, AMH and AFC on day 3 of menstrual cycle were measured. The relationship of these measured markers with outcome variables [oocytes number, number of frozen/fresh embryo and chemical and clinical pregnancy] was assessed in different age groups [i.e. 20-32, 33-37 and 38-43 years]
Results: our results show that age was correlated with clinical pregnancy, oocyte count and fresh and frozen embryo [p<0.001]. AMH, AFC and FSH were not correlated with clinical or chemical pregnancy at total population or age subgroups except the significant correlation of AFC with clinical pregnancy at 33-37 years old group. AFC was correlated with oocyte count and the number of fresh and frozen embryos in the ages group 20-32 years. In this age group, AMH was correlated with fresh and frozen embryos. AMH, AFC and FSH were correlated with oocyte count and the number of fresh embryos in age group 33-37 years. AMH was correlated with oocyte count and the number of fresh embryos in 38-43 years old group
Conclusion: we concluded that the age is the superior predictor of IVF outcome and AMH and AFC are variable predicting markers of ovarian reserve in different age groups