ABSTRACT
Candida species are present as normal body flora on the skin, buccal cavity, vagina and intestinal tract of many individuals. Low molecular weight protein produced by many intestinal microflora, inhibits the growth of Candida species, while broad-spectrum antibiotics kill most of these microflora, in turn Candida becomes activated and overgrow. to study the effect of Candida proteinase on some Gram-negative and Gram -positive bacteria. Pour plate method used to incorporate the tested bacteria in nutrient agar medium. Wells were punched with sterile cork porer. 40 of different concentrations of the enzyme was placed in each well. Zones of inhibition were measured after 24 hrs of incubation at 37°C. Concentrations of 40:1 and 20:20 were inhibitory for Klebsiella, E. coli and Enterobacter: While dilutions of iess than 50% of the enzyme were not effective against these bacteria, with the exception to lactobacilli