ABSTRACT
This an in-depth investigation of the relationship between some new aspects of positive family history [FH] of coronary artery disease [CAD] and other risk factors related to CAD in patients with acute myocardial infarction [AMI]. The data of 200 patients with AMI and positive FH of CAD [FH Pos.]- as case group- and 200 AMI patients without FH of CAD -as control group- [FH Neg.] were collected. Information about first and second-degree relatives was obtained, including age, occurrence of Ml, and other risk factors related to CAD. We also covered procedures such as coronary angiography [CAG], percutaneous intervention [PCI], and coronary artery bypass grafting [CABG] surgery. AMI with ST-segment elevation in ECG [69.61% vs. 26.76%], heart block [19.47%. vs. 6.34%], and low EF [mean 43 +/- 3.4% vs. 47 +/- 35%] were higher in the FH Pos. group than the FH Neg. group. As well as diabetes [42.71% vs. 11.27%], dyslipidemia [42.19% vs. 14%], and hypertension [73.74% vs. 64.79%] in the FH Pos. group were higher than those in the FH Neg. group. CAG [79.9% vs. 39.9%] and CABG [34.8% vs 14.79%] were higher in the FH Pos. group [all p values<0.05]. More patients in the FH Pos. group were male and younger, in the FH Pos. group, there was 65% positive finding in the second-degree relatives; most of these second-degree relatives came from the father's side [56%]. Also, there were 1.35 times more events in brothers than in sisters. Subjects with a positive family history of CAD were younger and more susceptible to CAD and needed frequent interventional procedures. Also, there was a difference in the power of various kinds of positive FH. In the FH Pos. arm, there was a stronger relationship between the patient and his/her brothers than with sisters and 56% incidence in the second-degree relatives [especially from the father's side]