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EJMM-Egyptian Journal of Medical Microbiology [The]. 1993; 2 (1): 81-86
in English | IMEMR | ID: emr-27752

ABSTRACT

This experimental study was carried on 20 guinea pigs with burn injury involving 40% of their body surface areas. Animals were classified into four groups, five animals in each: Group [I]: with thermal injury perse, Group [II]: Burn wound was immediately contaminated with pathogenic staphylococci and Pseudomonas pyocyaneus, Group [III]: intestinal decontamination was achieved by giving oral combination of penicillin, Streptomycin and Metronidazol and Group [IV]: Intestinal decontamination was achieved and then animals were orally contaminated with E. coli of known serotype [078 K 80 B-] obtained from a case of haemorrhagic gastroenteritis in Mansoura University Hospital. In all groups animals were killed 48 hours after induction of burn injury. The study showed that bacterial translocation occurred maximammly [100%] in group [IV], which were orally contaminated with E. coli. The same species of E. coli was harvested from the mesentric lymph nodes. In group [III] in which the intestine was decontaminate, only 20% showed bacterial translocation and at the same time the histopathological changes were minimal where there was no mucosal erosion or disintegration of lamina propria


Subject(s)
Animals, Laboratory , Bacterial Translocation , Guinea Pigs , Burns/immunology , Burns/microbiology
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