Percutaneous transthoracic needle aspiration, lavage and instillation of clindamycin-gentamycin in peripheral pyogenic lung abscess

Lung abscess are defined as localized suppurative necrotizing collection occurring within the pulmonary parenchyma. Some authors emphasized image-guided aspiration of lung abscess before antibiotics use in order to identify the pathogen. Antibiotic lavage is currently widely used in the treatment of patients with peritonitis, but not used previously in lung abscesses. Is to asses the role of percutaneous transthoracic needle aspiration, lavage and instillation of clindamycin-gentamycin on the treatment of peripheral pyogenic lung abscess. Twenty-six patients with peripheral pyogenic lung abscess are included in this study and classified into two groups. Group I received systemic empirical antibiotic, remod-ulated after the result of sputum culture and sensitivity. While group II underwent ultrasound guided percutaneous transthoracic needle aspiration, lavage and local instillation of antibiotics [clindamycin-gentamycin] associated with receiving systemic empirical parentral antibiotics, that were remodulated after the result of aspiration culture and sensitivity. Chest X-ray and chest ultrasound were done pre, post and after intervention by one week and before discharge. There was a statistically significant difference between group I and II as regard duration of systemic antibiotic use, duration of hospital stay, duration of radiological improvement, and size of abscess after intervention. Moreover complications occurred in group I were higher than in group II. Succeeded patients [according to clinical and radiological improvement of lung abscess] were more obvious among group II than group I. Aspirates culture and sensitivity revealed gram negative bacteria and anaerobic microorganisms, which are sensitive to local instillation of antibiotics [clindamycin-gentamycin]. Percutaneous aspiration of peripheral lung abscess has an accurate determination of the causative organisms inside the abscess. The resolution of the abscesses clinically and radiolog-ically was hastened by needle aspiration, lavage and instillation of clindamycin-gentamycin. Early intervention can improve symptoms, decrease morbidity and complications

Effect of hydrocele on testis and spermatogenesis

The present study was carried out on 50 patients with a large unilateral hydrocele to assess the effect of large unilateral hydrocele on structure and function of the testis. It is seen that a big hydrocele of tunica vaginalis is associated with impairment of spermatogenesis and atrophy of the testis

results of total excision and simple incision and drainage of cervical abscess

The present study included 30 patients with cervical tuberculous abscess. 20 patients were females and 10 patients were males, whose age ranged between 15-35 years. All of them subjected to full history, clinical examination and specific investigations for tuberculosis, 20 of them subjected to total excision of cervical abscess and 10 patients were underwent incision and drainage. For both groups chemotherapy was given. This study demonstrated that total excisions of tuberculous cervical abscess and infected lymph node can be done safely as primary procedure in treatment of cervical tuberculous abscess

Value of clinical evaluation and pressure study in diagnosis of varicose veins

Varicose veins of the lower extremities are one of the most important disorders of the peripheral vascular diseases. Pressure study was performed on 72 patients [43 females and 29 males]. The pressure was measured before and after exercise, before treatment and after treatment. The venous pressure and venous refill time was recorded. From this research, it was found that the pressure recording can diagnose the type of the disease but cannot tell the site of the lesion, so it cannot take the place of venography completely. However, with the aid of clinical examination and simple tourniquet tests, results equal to venography can be reached

Search for aspergillus by indirect immunoflorescence in asthmatic patients

This study included 50 patients with bronchial asthma, Every patient was subjected to detailed history, clinical examination, chest plain X-ray, skin test using aspergillus fumigatus antigen, direct microscopic examination of sputum for aspergillus fumigatus, indirect lmmunofluorescence examination of sputum and simple spirometry. Incomplete combination of the criteria for the diagnosis of allergic bronchopulmonary aspergillosis were observed in 1 case out of 50 asthmatic patients [2%]. The complete picture of allergic bronchopulmonary aspergillosis were not fulfilled in any patient included in this study

Calf-mother interrelationship: I-the effect of calf contact on milk parameters

Ten buffalo-low of a milking buffalo herd were used in this study to investigate the effect of calf contact on dam status [milk yield and composition as well as milking characteristics]. The experimental animals were divided into two groups: a] Suckling group in which calves were kept with their dams and suckled milk in a natural way. b] Milking group in which calves separated from their dams 3-5 days post calving the dams were hand milked and the calves suckled milk artificially via nipple pail. Daily milk yield was estimated milk samples were taken and analysed for fat%, lactose%, protein% and ash%. Morever, weekly determination of pre-milking stimulation, milking duration and milk flow rate were carried out for each animal. It was concluded that average daily milk yield was significantly higher [9.15 +/- 0.80 kg] in milking group than in suckling one [7.82 +/- 0.95 kg]. Average butter fat% was significantly higher in milking group [6.26 +/- 0.72 gm%] than in suckling one [5.59 +/- 1.1 gm%]. However, variations in lactose, protein and ash lacked significance [4.15 +/- 0.17 gm%, 3.90 +/- 0.18 gm% and 0.8 +/- 0.04 gm% in suckling group vs. 4.08 +/- 0.28 gm/%, 3.12 +/- 0.25 gm%, and 0.85 +/- 0.06 gm% in milking one respectively]. It was also found that pre-suckling stimulation was significantly shorter [2.02 +/- 0.37 minutes] than pre-milking stimulation [2.61 +/- 0.95 minutes]. Moreover, suckling duration was significantly longer than milking duration [7.06 +/- 2.01 vs, 4.66 +/- 0.67 minutes respectively]. Also, milk flow rate averaged 0.63 +/- 0.17 and 1.12 +/- 0.12 kg/minute for suckling and milking groups respectively and showed a significant variation

Calf-mother interrelationship: effect of calf contact on blood parameters

Ten buffalo-cows of a milking buffalo hred were used in this study to investigate the effect of calf contact on dam status [Blood profle mineral profile and total plasma proteins] the experimental animals were divided into two groups: a] Suckling group in which calves were kept with their dams and suckled milk in a natural way. b] Milking group in which calves were separated from their dams 3-5 days after calving and these dams were hand milked while the calves suckled milk artificially via nipple pial. Weekly blood samples were collected from the experimental animals for determination of haemoglobin red blood cells white blood cells and differential count. Blood plasma used for estimation of calcium, inorganic phosphorus, magnesium and total plasma proteins. It was concluded that the variations in crythrocytic and leucocytic counts as well as haemoglobin percentsage lacked significance due to suckling or milking. However suckling showed a clear lymphocytosis, eosinopenia and basopenia. Calcium and magnesium plasma levels were higher in the milking group than in suckling one [11.61 +/- 0.77 vs 11.15 +/- 0.35 gm% for calcium and 3.52 +/- 0.16 vs 3.17 +/- 0.15 gm% for magnesium]. Inorganic phosphorus level revealed no significant difference between group However, calph ratio was narrower in the suckling group [1.92:1] than in milking one [2.03:1]. Variation in total plasma protein percentage lacked significance between both groups [8.77 +/- 0.16 gm% in suckling vs 9.02 +/- 0.38 gm% in milking group]

Growth rate and behavioural patterns of buffalo calves under natural and artificial suckling conditions

Ten buffalo calves were used in this study to investigate the effect of natural and artificial suckling on growth rate behavioural patterns of buffalo calves during the first 3 months of life. The experimental calves were divided into 2 groups: a] Natural suckled calves: in which calves were with their dams and suckled milk in natural way. b] Artificial suckled calves: in which the calves were separated from their dams after colostral period [3-5 days] and the milk of each dam was given to its calf via nipple pail. Calves were weighed individually at weekly intervals during the experimental period for determination of absolute and instantaneous relative rate of growth and also some behavioural patterns within calves were recorded. The results indicated that absolute rate of growth/day was significantly higher [0.68 +/- 0.21 kg] in suckling group than in milking one [0.53 +/- 0.3 kg]. So, the suckled calves grew more quicker than other calves. Wagging the tails, butting each other, snoring in an enjoyable manner and playing are common characters in suckled calves. However, these behavioural patterns were not observed between calves of milking group. Also natural suckling associated with butting was a common problem within artificially suckled calves

Synthesis and biological activity of some new 1,3,4oxidiazolo-1,3,4-thiadiazolo and 1,2,4-triazolothienophrrimidines

Reaction of hydrazones 2 in acetic acid and sodium acetate mixture gave oxadiazolotheinopyrimidines 3. Also, the acid hydrazides 1 reacted with carbon disulfide and potassium hydroxide gave oxadiazolothienopyrimidines of the type 4. Moreover, compounds 6 were heated either with 2N NaOH triazolopyrimidines 7 or with orthophosphoric acid gave thiadiazolothienopyrimidines 8. The structures of the final products were confirmed by spectral and microanalytical data. Some of the prepared compounds were tested against a variety of Gram- positive and Gram-negative strains of bacteria

Studies on beta-lactans and thiazolidinones: part III: synthesis and biological activity of some new selena diazolyl-azetidin-2-ones and thiazolidin-4-ones

P-aminoacetophenone was smoothly condensed with semicarbazide to produce the corresponding semicarbazone [1]. The latter compound was oxidized with SeO 2 to give 4-[p-aminophenyl-4-yl]-1, 2, 3- selenadiazole [II]. Compound [II] was allowed to react with aromatic aldehydes to afford the corresponding Schiff bases [III]. Cyclocondensation of mercaptoacetic acid and chloro- acetyl chloride with compound [III] to give thiazolidinones [IV] and azetidinones [V], respectively. The constitution of some of the prepared products is discussed through their microanalysis and infrared spectra. The biological activities of some of these compounds were tested

Synthesis of some new thienopyrimidines containing 4-thiazolidinons moiety

The reaction of 4-mercaptopyrimidines 1 with halogenated active methylene compounds in aqueous sodium carbonate gave compounds 2a-h. Compounds 2c,g were allowed to react with hydrazine hydrate in ethanol to give the acid hydrazides 4a,b. The latter was condensed with aromatic aldehydes and ketones to give the corresponding hydrazones 5. Cyclocondensation reaction of thioglycolic acid with hydrazones gave thiazolidinothienopyrimidines 6