ABSTRACT
Indolemine 2, 3-dioxygenase [IDO] is a cytosolic monomeric hemoprotein enzyme that catalyses tryptophan, the least available essential amino acid in the human body, to N-formylkynurenine, which in turn rapidly degrades to give kynurenine. IDO is expressed in different tissues, especially and prominently in some subsets of antigen presenting cells [APCs] of lymphoid organs and also in the placenta of human and other mammals. Expression of IDO by certain dendritic cells, monocytes and macrophages has a regulatory effect on T cells probably by providing a tryptophan-deficient microenvironment and/or accumulation of toxic metabolites of tryptophan. This immunomodulatory function of IDO plays an essential role in different physiological and pathological states. IDO was shown to prevent rejection of the fetus during pregnancy, possibly by inhibiting alloreactive T cells. Moreover, IDO expression in APCs was suggested to control autoreactive immune responses. In this review we discuss the molecular and biological characteristics of IDO and its function in immune system as well as the potential application of this enzyme in improving the outcome of allogeneic transplantation as a local immunosuppressive factor
ABSTRACT
Background: the emotional changes of patients undergoing cochlear implantation [CI] has been addressed in a few studies. To date, no special test has been developed to measure these Changes
Objective: to measure the emotional status of children undergoing CI by interpreting their drawings
Methods: a prospective longitudinal study on prelingually deafened children from 4-14 years of age undergoing CI and sex and age-matched non-CI candidate deaf children comprised the study population. Drawings were produced before implantation and after 1, 3, 6, and 12-month intervals. These were scored with regard to a questionnaire developed in Amir Aalam Hospital Hearing Research Center, Tehran, Iran
Results: the prevalence of drawings with cues of rage/anxiety decreased from 35% to 21.9%. Similarly, sadness prevalence dropped from 36.8% to 20% and the prevalence of immaturity was reduced from 20% to 7.1%
Conclusion: we recommend drawing to be included in the rehabilitation program of children undergoing CI and used as a practical measure of their emotional progress