[In] vivo bioavailability studies of sumatriptan succinate buccal tablets

Sumatriptan succinate is a Serotonin 5- HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first - pass metabolism, resulting in a low absolute bioavailability of about 15%. The aim of this work was to design mucoadhesive bilayered buccal tablets of sumatriptan succinate to improve its bioavailability. Mucoadhesive polymers carbopol 934 [Carbopol], HPMC K4M, HPMC K15M along with ethyl cellulose as an impermeable backing layer were used for the preparation of mucoadhesive bilayered tablets. In vivo bioavailability studies was also conducted in rabbits for optimized formulation using oral solution of sumatriptan succinate as standard. Bilayered buccal tablets [BBT] containing the mixture of Carbopol and HPMC K4M in the ratio 1:1 [T1] had the maximum percentage of in vitro drug release within 6 hrs. The optimized formulation [T1] followed non-Fickian release mechanism. The percentage relative bioavailability of sumatriptan succinate from selected bilayered buccal tablets [T1] was found to be 140.78%. Bilayered buccal tablets of sumatriptan succinate was successfully prepared with improved bioavailability

Formulation and evaluation of mouth dissolving tablets of the etoricoxib

The demand for mouth dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. Etoricoxib is a new non-steroidal anti-inflammatory drug [NSAID] with selective cox-2 inhibitory activity, selective inhibition of cox-2 provides anti-inflammatory and analgesic activity it is commonly used for osteo-arthritis, rheumatoid arthritis, primary dysmenorrhoea, post operative dental pain and acute gout. The main criteria for mouth dissolving tablets are to disintegrate or dissolve rapidly in oral cavity with saliva in 15sec to 60sec with need of water. The disintegrants used should fulfill the criteria by disintegrating the tablets in specified time limit.in the present investigation variety of super disintegrants like primogel, kollidone, Ac-Di-sol, L-HPMC, L-HPC, were selected and tablets were prepared by direct compression method in different concentration like 4% and 8%. The prepared tablets were evaluated for weight variation, hardness, friability, in vitro disintegration time, wetting time, in vitro dissolution study, etc. formulation f-9 shows the lowest disintegration time [44sec] and wetting time [52sec]. In vitro dissolution studies revealed that formulation F-9 containning 8% L-HPC showed 97% drug release at the end of 20 min

Anti-inflammatory activity of aerial parts of tephrosia purpurea linn.

The crude extracts of aerial parts of Tephrosia purpurea Linn. was tested for anti-inflammatory activities. The effect of ethanolic and aqueous extracts were investigated in rats to evaluate the anti-inflammatory activity. Carrageenan-induced and histamine-induced rat paw oedema methods were employed to test anti-inflammatory activity. The ethanolic and aqueous extracts [250 mg/kg] showed the inhibition of carrageenan-induced rats paw oedema and also found to be effective in histamine-induced method. The results indicate that both ethanolic and aqueous extracts showed significant [P<0.001] anti-inflammatory activity when compared to control

In vitro antioxidant activity of roots of Thespesia lampas Dalz and Gibs

The free radical scavenging potential of roots of Thespesia lampas Dalz and Gibs was studied by different antioxidant models. Free radicals are implicated for more than 80 diseases including Diabetes mellitus, arthritis, cancer, ageing etc. In the treatment of theses diseases, antioxidant therapy has gained an utmost importance. Current research is directed towards finding naturally occurring antioxidant of plant origin. In Indian system of medicine, Thespesia lampas is an important medicinal plant and its root juice has been used in various ailments and as health tonic. To understand the mechanisms of pharmacological actions, the in vitro antioxidant activity of aqueous extract of Thespesia lampas was investigated for the activity of scavenging superoxide anion radicals, nitric oxide radical and lipid peroxidation assay. In all the testing, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals, metal chelating, reducing power or inhibition of lipid peroxidation. These results clearly indicate that Thespesia lampas is effective against free radical mediated diseases

Antiulcer effect of trichosanthes anguina against gastric ulcers in rats

The effect of alcoholic extract of Trichosanthes anguina was investigated in rats to evaluate antiulcer activity by using pyloric ligation and aspirin induced ulcer models. The parameters taken for antiulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicate the alcoholic extract significantly [p<0.001] decreased the volume of gastric acid secretion, free acidity, total acidity and ulcer index with respect to control