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Background: The current threat of Covid-19 pandemic is not only disrupting the economy but also creating psychological impact on the people. As a measure to control the spread, India imposed lockdown on various occasions. During this period only essential services were operational, while educational institutions remain closed. Due to social distance norms and restricted recreational activities, children are more prone to behavioural changes and it can also cause anxiety and depression. The current study focusses upon this aspect among school going children due to Covid-19.. Methodology: A cross sectional study was done on school going children, currently restricted to home. A semi-structured questionnaire which included (RCADS-25 scale for depression and anxiety) was administered to the parents through online platform. Bivariate logistic regression was used to test the significance of association between changes Impact of covid-19 and emotional status of Children and also between behavioural changes in children and presence of at least one sibling. Results: Majority of respondents were males (59%) and mean age was 9.9yrs. Majority (47.2%) belong to Middle school. Mean score of RCADS-25 scale was 15.61±9.4 for the study population. Worry was seen in 67.3% and frustration was seen in 32.4% for conduction of online classes. Irritability was seen 31.91% and restriction of outdoor activities caused loss of temper in 56.9% of the study population. Insomnia was often seen in 20% while 50% had sadness/empty feeling at some point of time. Lack of confidence was seen in 52.7% children. Majority (69.5%) were scared to sleep alone at night. Chi-square test for significance showed significant association between Parent’s behaviour and mood changes in Children (O.R- 2.43(1.1-5.33 - 95%C. I) p=0.04). Bivariate logistic regression showed significant association between Impact of covid-19 and emotional status of Children (O.R=2.967,95% C.I(1.582-5.564), p=0.001) and also between behavioural changes during pandemic and presence of at least one sibling(O.R =0.578,95% C.I 0.345-0.971,p=0.038). Conclusion: The behavioural changes of children due to Covid -19 is evident and necessary measures like counselling the parents are necessary
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The aim of the study was to investigate the antimicrobial susceptibility pattern of Klebsiellaspecies from different clinical samples at Sree Balaji Medical College and Hospital, India. Overall 189 samples out of 980 non repetitive clinical samples obtained from wound/pus, urine, sputum swab and blood by disc diffusion method and identified as Klebsiellaand analysed. Out of total 189 Klebsiellaisolates, 76 out of 155 K. pneumoniae(49%)were resistant and none out of 34 Klebsiella oxytoca(0%) showed resistance to cefotaxime and ceftazidime by disc diffusion method. Antimicrobial susceptibility testing of Klebsiellaexhibited 100% resistance to Ampicillin. The present study highlights the need for the continued monitoring of antimicrobial susceptibility patterns of important bacterial pathogens, so that rational antibiotic policies can be formulated
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Introduction: The subtrochanteric fractures are one of thecommon fractures that every trauma surgeon come acrosson daily basis. The most of these fractures are treated eitherintramedullary device or a side plate. Among side plates, thechoice between the implants like DCS and DHS is variedamong the different surgeons. We made an analysis of resultsof Dynamic Condylar Screw with the aim to find out the useof that implant in selective fracture types.Material and Methods: A prospective study during 2014 to2015 was done in our institute. The study period is 1 year. Thepatients who opted for surgical treatment only were chosen.They were undergoing surgery under spinal anaesthesia, usingfracture table under image intensifier. The position of fracturereduction was checked in anterior posterior and lateral imageintensifier views. The post-operative assessment was doneat 3weeks, 6 weeks and 3months intervals with regard toradiological union and clinical outcomes. Data was analysedand expressed in terms of percentages.Result: the female to male ratio was 1:1.55. The average ageamong males is 58years and of females is 54 years. The rightside and left side were involved equally (n=28). Most of thepatients were injured by fall at home 39.2% (n=11), due toRTA 32.1% (n=9) and 28.5% (n=8) subjects were injureddue to self-inflicted road accidents. Limb shortening is mostcommon complication, which is there for 17.85% (n=5) ofpatientsConclusion: Dynamic Condylar Screw (DCS) provide goodfixation for subtrochanteric fractures with better results interms of stability and fracture union. Procedure has a fewercomplication rates if cases were selected carefully.
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Unna thost syndrome is Palmo Plantar Keratoderma (PPK) of diffuse non epidermolytic type inherited in autosomal dominant fashion. Authors had a seven-year-old boy born to second degree consanguineous parents had palmoplantar keratoderma with hyperhidrosis with positive family history. He was promptly diagnosed and treated with acitretin and showed improvement.
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Background: Skeletal muscle relaxants are structurally distinct drugs prescribed for reducing muscle spasms, pain, and hyperreflexia. Centrally acting skeletal muscle relaxants are manufactured by various pharmaceutical companies with variable price. The present study, aimed to analyze the cost variation of various brands of centrally acting skeletal muscle relaxants, so as to help the physician to choose the cost effective treatment.Methods: Current index of medical stores (CIMS) April 2018 and online literature were used as information guide to review the prices of drugs used in the treatment of musculo skeletal pain and spastic neurological disorders.Results: Among anti spasmodic group, thiocolchicoside 4 mg shows maximum price variation of 337.5%, whereas carisoprodol 350 mg shows the least variation of 0.1%. It is evident from antispastic group that baclofen 10 mg shows maximum price variation of 93.91% and 5 mg of Baclofen shows the least variation of 11.22%. It is observed that, among anti spastic group, a percentage prize variation of 93.91 for 10 mg and 11.22 for 5 mg baclofen. Largest % prize variation is seen in metaxalone + diclofenac sodium (400+50) mg as 525% and the least variation is observed in tolperisone+ paracetamol (150+325) mg as 3.88%.Conclusions: Centrally acting orally effective skeletal muscle relaxants are commonly prescribed for painful musculoskeletal and spastic neurological disorders. Physicians should give due importance for the cost of the drugs while selecting appropriate drug for musculo skeletal disorders.
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Injured/spoiled fruits like Banana, Orange, Grapes and Pomegranates were collected locally from fruit market. Prosopis juliflora pods were collected from university campus and all the fruit substrates were dried in a hot air oven at 60 0C for 8 hours. The amount of Tannin (Catechin) present in different fruit substrates were estimated by standard AOAC method. Tannins acting as anti nutrients were detoxified by using 5% Ca (OH)2 method. 100 g of each detoxified and non detoxified fruit substrate were boiled in 1 liter distilled water to obtain 10 per cent fruit extract followed by centrifugation at 5000 rpm for 5 minutes to remove sediments and impurities. 100 ml of each fruit extract medium was taken into 250 ml conical flask, sterilized by autoclaving and inoculated with 1 per cent probiotic yeast Saccharomyces cerevisiae (OBV9) and incubated. After incubation, optical density (OD660) and cell packs were determined. Based on the yield of yeast, availability of substrates and cost, among all the fruit extracts Prosopis juliflora was selected for further studies.
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Background and Objectives: Serotonin transporter polymorphisms, 5-HTTVNTR and 5-HTTLPR, have been found to be associated with obsessive-compulsive disorder (OCD) and particularly with neurotic characteristics. In the present study we looked for an association between OCD and these polymorphisms in OCD patients and controls of south Indian origin. Methods: 5-HTTVNTR and 5-HTTLPR/rs25531 were genotyped in 93 OCD patients and 92 healthy controls. The allelic distribution and genotype frequency in cases and controls were compared using chi square test. In order to test for the effects of genotype on heterogeneity of the illness, linear regression analysis was undertaken for co-morbid depression status and YBOCS score (severity index). Results: There was no significant association with the 5-HTTVNTR or the 5-HTTLPR polymorphism. No significant association of OCD with the 5-HTTLPR genotype was found even on inclusion of the rs25531 locus, which is part of the transcription factor binding site as reported in earlier studies. However, severity of the illness showed a modest association with the dominant model. Interpretation & conclusions: Our data show that genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population. Further replication in a large and independent cohort with an equal number of female subjects would help to ascertain if the absence of association in this cohort is due to the nullifying effect of the larger proportion of male subjects in our sample population. The marginal effect of the 5-HTTLPR (A/G) genotype obtained on linear regression with disease severity is suggestive of a potential role for this locus in the disease process.