[ frequency of microscopic colitis in the patients with chronic diarrhea in Kurdistan province in 2009]

Microscopic colitis is a cause of chronic watery diarrhea which may be accompanied with abdominal pain and weight loss. The purpose of this study was to determine the frequency of microscopic colitis in the patients with chronic diarrhea in the subspecialty center in Sanandaj in 2009. This was a cross sectional study and included 115 patients with non-bloody chronic diarrhea in Sanandaj in 2009. Sampling method was census. Demographic data were recorded in a checklist for every patient. Then colonoscopy was performed and biopsy samples were obtained for pathological examination and determination of the type of colitis. Fifty patients [%43.4] had microscopic colitis [4.3 collagenous and%39.1 lymphocytic] and 65 patients [%56.6] had not this disease. Female to male ratio was 2 to 3. The majority of the patients were under 40 years of age and the mean values of the age of the patients with collagenous and lymphocytic colitis were 29 and 35.4 years respectively. The frequency of microscopic colitis [lymphocytic and collagenous] in the patients with non-bloody chronic diarrhea was high and the age of onset of this disease in Kurdistan was low, while in other parts of the world the disease occurs in the individuals over 50 years of age

[Lipoid proteinosis: a case report from Kurdistan Province in 1390]

Lipoid proteinosis is a rare metabolic autosomal recessive disorder. Clinical manifestations of this disease are attributed to deposition of hyaline material in dermis and other organs which is a consequence of genetic mutations. Hoarseness of voice, beaded papules on the eyelid margins, acneiform scars, waxy papules and warty papules are common clinical manifestations of this disorder. Other manifestations include speech disorder, photosensitivity, recurrent salivary gland inflammation, loss of eyelashes, alopecia of scalp and pruritus. A 17 year old boy developed hoarseness of voice and mucocutaneous lesions since infancy. Skin lesions included acneiform scars on the face, waxy papules and warty papules on the elbows and buttocks, and also beaded papules on the eyelid margins .The tongue of the patient gradually enlarged and some papules appeared on the tongue and mouth angles. The patient was not able to protrude his tongue out of the mouth. Histopathologic examination revealed deposition of pink amorphous [hyaline] material in the dermis and around skin appendages. Diagnosis of lipoid proteinosis is based on its clinical manifestations and histopathological findings. Once hoarseness of voice in infancy, which is among the most common and earliest manifestations of the disease, is detected, lipoid proteinosis should be considered as an important differential diagnosis