Effect of clausena dent at a [WILLD.] M. Roem. against paracetamol induced hepatotoxicity in rats

Ethanol extract of Clausena dentata [Willd.] M. Roem [Rutaceae] was evaluated for hepatoprotective activity in rats. The plant extract [250 mg/kg, p.o.] showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum markers for liver damage. Acetaminophen induced a signi-ficant rise in aspartate amino transferase [AST], alanine amino transferase [ALT], alkaline phosphatase [ALP], total bilirubin, gamma glutamate transpeptidase [GGTP] and decrease in total protein. Treatment of rats with ethanol extract [250 mg/kg] significantly [P < 0.001] altered serum marker enzymes levels to near normal against acetaminophen treated rats. The activity of the extract was comparable to the standard drug, silymarin [50 mg/kg, p.o.]. Histopathological changes of liver sample were compared with respective control. Results indicate that Clausena dentata possesses hepatoprotective effect on acetaminophen-induced hepatotoxicity in rats

Anti-bacterial activity of ethanolic extract of indoneesiella echioides [L] Nees. evaluated by the filter paper disc method

The study was carried out to investigate the antibacterial activity of the ethanolic extracts of Indoneesiella echioides [L] Nees. was evaluated by the filter paper disc method. This method is based on the diffusion of an antibiotic from a filter paper disc through the solidified culture media of a Petri dish used for study. The growth of inoculated is inhibited entirely in a circular area 'Zone around the filter paper disc containing a solution of antibiotic and the plant extract. The microorganisms used were: 1. Staphylococcus aureus [Gram positive 2. Escherichia coli [Gram negative] The organisms were maintained on nutrient agar slants. These were tested using nutrient broth. One loop ful of the respective cultures was taken in slants which were maintained below 40oC were taken and inoculated in the broth and incubated at 37oC for 24hrs and were observed for the growth of the organism with naked eye for their turbid nature. It was compared with that of sterile broth. The presence of turbidity indicated growth and suitability of the culture for further work

Antitumor activity of pandanus fascicitlaris Lam. on Dalton's ascitic lymphoma [DAL] in mice

Antitumor activity of ethanol extract of Pandanus fascicularis Lam. [EPF] was studied in mice. The antiturnor activity of EPF was evaluated against Dalton's ascitic lymphoma [DAL] tumor model on dose dependent manner. The activity was assessed using survival time, average increase in body weight, haemalological parameters and solid tumor volume. Oral administration of EPF increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation. EPF is able to reverse the changes in the haematological parameters, protein and PCV consequent to tumor inoculation. Oral administration of EPF was effective in reducing solid tumor mass development induced by DAL cells. The results show that EPF possess significant antitumor activity in dose dependent manner

Antiulcer effect of trichosanthes anguina against gastric ulcers in rats

The effect of alcoholic extract of Trichosanthes anguina was investigated in rats to evaluate antiulcer activity by using pyloric ligation and aspirin induced ulcer models. The parameters taken for antiulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicate the alcoholic extract significantly [p<0.001] decreased the volume of gastric acid secretion, free acidity, total acidity and ulcer index with respect to control