ABSTRACT
Adverse drug reaction (ADR) is defined as “any response to drug which is noxious or unintended and occurs at a dose normally used in man for prophylaxis, diagnosis or treatment of diseases or for modification of physiological function”. Among the ADRs reported, cutaneous drug reactions are most common. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), also known as baboon syndrome (BS), is included in the spectrum of systemically induced allergic contact dermatitis. Characteristics of SDRIFE include a sharply defined symmetric erythema in the gluteal area and in the flexural or intertriginous folds without any systemic symptoms or signs. We present a case of 30-year-old female with baboon syndrome after taking the combination of paracetamol and diclofenac. Awareness of SDRIFE (BS) as an unusual drug reaction is especially important since the connection between skin eruption and drug exposure may easily be overlooked or misdiagnosed.
ABSTRACT
Background: The objective of this study was to evaluate efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced swiss albino mice.Methods: Study was placebo controlled, randomized laboratory based comparative study with prior permission of Institutional animal ethical committee. Experimental animals were divided in to seven groups as control (distilled water 10ml/kg), standard Fluoxetine two doses (10mg/kg and 20mg/kg) , test drug ondansetron three doses (0.5mg/kg, 1mg/kg and 2mg/kg) and combinations of test and standard (0.5mg/kg + 10mg/kg).The drugs were administered intraperitonium and antidepressant activity was recorded using physically induced depression models tail suspension test and despair swim test.Results: Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Combination doses showed stastically significant antidepressant activity.Conclusions: The present study indicates ondansetron showed promising antidepressant activity due to its ability to modulate serotonergic system and has proved to be safe in the dose range of 0.5mg/kg, 1mg/kg and 2mg/kg in mice.
ABSTRACT
Background: Many antiepileptic drugs were introduced for the treatment of epilepsy. Ideal antiepileptic drug should not only prevent but also correct the underlying pathophysiology without altering the normal neurotransmission. Calcium channel blockers may form such group because initiation of seizure is associated intrinsic burst firing which is triggered by large inward calcium current, so this study was done to evaluate the anticonvulsant effect of amlodipine in albino rats.Methods: A total of 42 adult albino rats were included in the study and divided into 7 groups, each containing 6 rats. Group 1 received distilled water, group 2,3 received sodium valproate 50mg/kg and 100mg/kg, group 4-6 received amlodipine 1, 2, 4mg/kg and group 7 received combination of Amlodipine 1 mg/kg and sodium valproate 50mg/kg. Pentylenetetrazole induced seizures model was done and onset of myoclonic jerks, onset of clonic convulsions and duration of clonic convulsions was studied.Results: There was a significant anticonvulsant effect in Amlodipine doses 2, 4mg/kg (p <0.001). The combination of Amlodipine (1mg/kg) and Sodium valproate (50mg/kg) also had significant anticonvulsant effect.Conclusions: Amlodipine, a calcium channel blocker has anticonvulsant effect and also potentiated the anticonvulsant effect of low dose sodium valproate.