Synthesis and biological activity of some new 1,3,4oxidiazolo-1,3,4-thiadiazolo and 1,2,4-triazolothienophrrimidines

Reaction of hydrazones 2 in acetic acid and sodium acetate mixture gave oxadiazolotheinopyrimidines 3. Also, the acid hydrazides 1 reacted with carbon disulfide and potassium hydroxide gave oxadiazolothienopyrimidines of the type 4. Moreover, compounds 6 were heated either with 2N NaOH triazolopyrimidines 7 or with orthophosphoric acid gave thiadiazolothienopyrimidines 8. The structures of the final products were confirmed by spectral and microanalytical data. Some of the prepared compounds were tested against a variety of Gram- positive and Gram-negative strains of bacteria

Studies on beta-lactans and thiazolidinones: part III: synthesis and biological activity of some new selena diazolyl-azetidin-2-ones and thiazolidin-4-ones

P-aminoacetophenone was smoothly condensed with semicarbazide to produce the corresponding semicarbazone [1]. The latter compound was oxidized with SeO 2 to give 4-[p-aminophenyl-4-yl]-1, 2, 3- selenadiazole [II]. Compound [II] was allowed to react with aromatic aldehydes to afford the corresponding Schiff bases [III]. Cyclocondensation of mercaptoacetic acid and chloro- acetyl chloride with compound [III] to give thiazolidinones [IV] and azetidinones [V], respectively. The constitution of some of the prepared products is discussed through their microanalysis and infrared spectra. The biological activities of some of these compounds were tested

Synthesis of some new thienopyrimidines containing 4-thiazolidinons moiety

The reaction of 4-mercaptopyrimidines 1 with halogenated active methylene compounds in aqueous sodium carbonate gave compounds 2a-h. Compounds 2c,g were allowed to react with hydrazine hydrate in ethanol to give the acid hydrazides 4a,b. The latter was condensed with aromatic aldehydes and ketones to give the corresponding hydrazones 5. Cyclocondensation reaction of thioglycolic acid with hydrazones gave thiazolidinothienopyrimidines 6