ABSTRACT
Improving the diagnostic strategy of the lupus anticoagulant is prerequisite in hemostasis. The objective of our work is to develop and evaluate the three integrated tests expressed as normalized ratio or Lupus Ratio and can combine the various stages in the diagnosis of these antibodies. Three Lupus Ratio are used, they were determined with activator thromboplastin time, the diluted thromboplastin time and diluted Russell Viper venom time. Reference values and thresholds for positivity were determined for all tests. Our preliminary results showed concordant and discordant profiles with those previously obtained by conventional methods of detection of circulating lupus antibody type. The interest of the integrated testing is to discusse and compari our results with those of the literature. The determination of the Ratio Lupus offers compelling and promising results and allows considering, for in a short term, the replacement of conventional techniques with improved diagnosis