ABSTRACT
Multidrug resistant strain of S. aureusis the most common cause of life-threatening hospital-and community-acquired infections. Multidrug resistant S. aureusinfections contribute to patients’ prolonged stay in the hospital, increase in total healthcare costs, morbidity, and mortality.This work was aimed at determining the occurrence and antibiotic susceptibility profile of Staphylococcus aureusisolated fromsome clinical samples (blood and urine) in General Hospital, Nasarawa, Nasarawa State, Nigeria. All the 14 samples (7 each for blood and urine) collected in this study yielded positive for S. aureus,which were identified by cultural appearances and confirmed using conventional biochemical tests.The antibiotic susceptibility profile of the isolates indicated that, majority of them exhibited high susceptibility to gentamycin (85.7%), ciprofloxacin (78.6%), vancomycin (71.4%), chloramphenicol (64.3%), teicoplanin (50.0%), and erythromycin (42.9%). All the 14 (100%) isolates tested showed resistance to oxacillin, amoxicillin (85.7%), and cefoxitin (78.6%).