Investigating different health implications due to occupational exposure to vinyl chloride in an Egyptian PVC production facility

The present study aims at investigating possible health hazards due to occupational exposure to vinyl chloride monomer [VCM] and polyvinyl chloride [PVC]. Relevant haematological, liver and renal functions, tumour markers, roentegenograms of the chest and peripheral [distal] ends of the short- long bones [of hands and wrists], ultrasonographic parameters of the liver and abdominal organs as well as chromosomal aberrations are evaluated for 182 workers, chosen on simple random basis, from different sections at an Egyptian facility manufacturing VCM and PVC. Air measurements were taken at the breathing level at different sections. The highest VC levels were detected at the liquid waste treatment, VCM emergency scrubber tower, direct chlorination sections, the reactors' areas. Clinically, more than 80% of the studied workers have one or more symptoms and / or signs affecting their respiratory, digestive, circulatory, liver, renal, or musculoskeletal system. The onset of the majority of the elicited manifestations proved to be after the start of their work at the VCM / PVC manufacturing plant. About 44% of the studied workers had one or more abnormal ultrasonographic findings; 39.3% had abnormal liver [as regard the size or pattern], 20% had abnormal spleen, 5.8% had abnormal renal pattern. Eight workers had positive chest x- rays for interstitial pulmonary fibrosis or emphysema, and eight workers had osteolytic bony lesions affecting the peripheral areas of their distal phalanges in both hands. Positive antinuclear antibodies [ANA] was elicited in sera of 28 workers [15.4%]. All, except four workers have chromosomal aberrations in various forms: gaps, breaks, deletins. isogaps, isobreaks, dicentrics, centromere separation, as well as polyploidy. The study pointed out the presence of serious exposure to vinyl chloride, higher than the recommended TLV, in different locations. The clinical study revealed many adverse health effects which strongly suggest the relation with either acute, chronic, and / or delayed consequences of the occupational VCM/PVC exposure. Adopting preplacement and periodic medical examinations as well as provision of suitable protective clothing and equipment for workers at VCM / PVC manufacturing sections. Addition of "VCM / PVC Exposure and Consequent Effects" to the Egyptian List of Occupational Diseases. Good training is important for improving the working behaviour. Continuous monitoring of VC and related compounds should be a routine procedure

Amniotic fluid interleukin - 6 [il-6] determination: a possible guide for management and prognosis of preterm labour

Amniotic fluid samples were collected from four carefully selected groups of pregnant women, respectively, presented as followed [but none with any evidence of intrauterine infection]: Group I, term pregnancy not in labor; group II, normal term labor; group III, preterm labor and undelivered within one week of sampling and group IV, preterm labor and delivered within one week of sampling. Amniotic fluid was obtained by amniocentesis [in undelivered women] or at the time of amniotomy [in delivered women]. The samples were cultured to detect any intrauterine infection. Interleukin-6 [IL-6] was determined by a specific enzyme-linked immunoassay. The mean [ +/- SD] amniotic fluid IL-6 levels [pg/ml] were 25.5 +/- 6.2 in group I, 504 +/- 60.6 in group II, 45 +/- 15.1 in group III and 406 +/- 100.7 in group IV. However, insignificant difference in the IL-6 levels was found between the women of group II and group IV, a significant difference was noticed in the IL-6 levels between the undelivered [groups I and III] and delivered [groups II and IV] women whether in term or preterm labor. Therefore, it was concluded that the determination of IL-6 level in amniotic fluid may help in the prognosis and management of preterm labor

Helicobacter pylori infection as a risk factor for coronary heart disease

The work included 17 coronary diseased patients and 10 controls, their mean ages were 56.4 +/- 12 years vs 46.3 +/- 15.2 years, respectively. Electrocardiography, echocardiography, cardiac enzymes levels in blood, lipid profile together with IgG and IgA to detect Helicobacter pylori infections were done to both coronary heart disease and control groups. The results showed that H. pylori infections were detected in 41% of CHD patients and control group, respectively, while recent infections was detected in 47% of CHD patients, it was doubtful in 24% with no recent infection in 29% of them as showed by IgA. For the control group, none had recent infections and 20% of them were doubtful. H. pylori seropositivity was inversely related to the level of HDL in both the CHD and the control patients