ABSTRACT
Aims:The purpose of this study is to identify the medicinal plants used in the bistros and to determine the preference between the consumption of Koutoukou alone or the Koutoukou mixture associated with medicinal plants in the city of Abidjan.Place and Duration: Pharmacodynamic Biochemical Laboratory, Faculty of Biosciences, University Félix Houphouët-Boigny, between December 2017 and June 2018.Methodology: The investigation took place in the neighborhoods of Abobo, Cocody, Koumassi and Yopougon. This is an open-ended questionnaire intended for consumers of Koutoukou alone and association of medicinal Plants-Koutoukou. The identity, the region, the marital and professional status of the consumers on the one hand, the ethnobotany of the medicinal plants used and their associations with Koutoukou on the other hand were consideredResults: This study identified 12 species of medicinal plants commonly used in bistros. 70% of the surveyed population prefer and consume more cocktails at the expense of simple koutoukou. The Garcinia kola-Koutoukou combination is the most significantly consumed cocktail (Number of treated illnesses greater than 10). Conclusion:This descriptive study resulted in the identification of 12 medicinal plants commonly used in the bistros of 4 Commune of the city of Abidjan and consumed in association with Koutoukou. The populations of these municipalities (70%) greatly appreciate. TheMost consumed is the association of Garcinia kola-Koutoukou for his righ rate of healing.
ABSTRACT
Aim: This study aims at evaluating the effects of Wakouba, an extract of the fronds of oil palm tree Elaeis guineensis (Jacq) traditionally used in the treatment of high blood pressure, on lipid profile, urea, creatinine, blood glucose, systolic blood pressure (SBP), diastolic (DBP) and heart rate (HR) in hypertensive rabbits. Methods: Twenty four rabbits (24) divided into six (06) groups of four rabbits each weighing between 1.5 ±3.0 to 2± 1.5 kg were used. Group 1 served as witness, group 2 sick and untreated control, groups 3, 4, 5, and 6 were used as experimental groups (sick+treatment). Throughout the experiment the witness group received distilled water; adrenaline was administered to the sick control group. After 10 days of adrenaline injection, hypertension has been stabilized in sick groups (group 2 to 6) and blood was taken for the determination of urea, creatinine, and lipids. Four (04 ) of the five (05 ) groups of hypertensive rabbits were treated with two (2) doses of " Wakouba " 950 and 2500 mg / kg bw and two ( 02) doses of ténordate 10 and 20 mg / kg BW, two(2) group by two(2) group . After ten (10) days of treatment, the SBP and DBP and HR were measured, blood was collected for determination of the same biochemical parameters. Results: The study of the effect of Wakouba and ternodate on the changes in systolic blood pressure SBP, DBP and heart rate (HR) showed a significant decrease (P<0.05 ) up to normalization of these parameters after 10 days of treatment. Similarly, the measurement of serum lipid profile in hypertensive rabbits treated with Wakouba (950mg / kg bw) and tenordate (20 mg / kg bw) showed a significant reduction in (P<0.05) values of total cholesterol, LDL cholesterol and triglycerides in contrast to HDL cholesterol which has increased significantly compared to the control group. Same doses also normalize serum glucose, urea and creatinine. Histological sections performed on the kidney and the heart of hypertensive rabbit showed congestion of blood in the kidney and cardiomyopathy. Conclusion: Wakouba at dose (950 mg / kg bw) as well as tenordate decreases and normalizes systolic blood pressure (SBP ) , diastolic blood pressure (DBP ) and heart rate (HR) in hypertension induced rabbit . Furthermore Wakouba (950 mg / kg BW) and tenordate (20mg/kg BW) increases HDL cholesterol and decrease LDL cholesterol. Wakouba would have the same mechanism of action as tenordate (ATENOLOL + NIFEDIPINE) a reference anti hypertensive product, thus anti hypertensive and cardioprotective properties, which justifies it uses in traditional medicine in Cote d’Ivoire as an anti hypertensive.
ABSTRACT
Purpose: The objective of the study was to investigate the ethyl acetate extract of Morindamorindoides (Baker) Milne-Redh (Rubiaceae) (MM-EA) properties against experimental diarrheoa induced by castor oil in albino Wistar rats. Methods: The ethyl acetate extract of Morinda morindoides (250; 500; and 1000 mg/kg body weight) was administered orally to three groups of rats (five animals per group) in order to evaluate the activity of the extract against castor oil-induced diarrhea model in rat. Two other groups received normal saline (5mg/kg) and loperamide (5mg/kg) as positive control. The effect of the extract on intestinal transit and castor oil-induced intestinal fluid accumulation (enteropooling) was assessed. Results: At oral doses of 250; 500; and 1000 mg/kg body weight; the plant extract showed pronounced and dose-dependent antidiarrheal activity. The protective role of the extract at 1000 mg/kg was comparable to that of the reference drug; loperamide (5mg/kg). The extract (1000 mg/kg) produced a decrease in intestinal transit comparable to atropine (5mg/kg); and significantly (p0.01) inhibited castor oil-induced enteropooling. No mortality and visible signs of general weakness were observed in the rats following the extract administration of up to a dose of 6000 mg/kg. Conclusion: The results showed that the extract of M. morindoides has a significant antidiarrheal activity which supports its use in traditional herbal medicine practice