ABSTRACT
Graham-Little-Piccardi-Lasseur syndrome [GLPLS] is a rare variant of lichen planopilaris comprising of a triad of multifocal cicatricial alopecia of scalp, non-cicatricial alopecia of axillae and pubic region and keratotic follicular papules over body. Its exact etiology is not known to date, but it primarily involves an immune mediated inflammation affecting hair follicles resulting in cicatricial alopecia. We report a case of 55 years old female diagnosed as having features of this syndrome with cicatricial alopecia of FFA and FADP.
ABSTRACT
The aim of our study was to determine the levels of ESR and CRP in psoriasis with/without psoriatic arthritis and to find whether there is any correlation of their values with its severity and presence or absence of psoriatic arthropathy. Prospective study. This study was conducted at Jinnah Postgraduate Medical Centre, Karachi from January 2014 to August 2014. 60 patients, 35 males and 25 females were enrolled. After detailed history and severity assessment by PASI, blood was sent for ESR and CRP levels. All data was documented and analyzed. There were 60 patients [35 males and 25 females] with age ranging from 20-65 years and had a history of psoriasis from 1-38 years. 89% had chronic plaque psoriasis and 30% had psoriatic arthropathy. PASI score ranged from 4-26 [Mean 7.92 -/+ 6.38]. The means of ESR and CRP were 16.44 +/- 12.66 mm/hr and 3.84 +/- 3.63 mg/L respectively. Neither ESR nor CRP levels directly correlated with PASI or with psoriatic arthropathy. ESR and CRP doesn't seem to have prognostic significance in mild to moderate psoriasis and psoriatic arthropathy. However there might be any role of ESR or CRP in patients with severe psoriatic arthropathy
Subject(s)
Humans , Adult , Female , Male , Middle Aged , C-Reactive Protein , Blood Sedimentation , Arthritis, Psoriatic , Prospective StudiesABSTRACT
Oculocutaneous albinism is a disease with an autosomal recessive inheritance pattern in most cases. People with Oculocutaneous albinism face many health, psychological and financial issues. In this study, we report a unique village of Bhatti tribe in Jacobabad District, Pakistan, in which 40 children and adults with albinism live. The aim of this study was to observe the pattern of inheritance, complications and socioeconomic impacts of this condition on the community. Detailed clinical history and relevant data were recorded on a specially designed performa followed by clinical examination by a consultant dermatologist together with his team to observe the extent of the disease and associated complications in two seasons [winter and summer]. This village, with a total population of 810, had 40 cases, 17 male and 23 female, ranging in age from 6 months to 35 years. About 65% of the affected individuals were younger than 16 years of age. There were 22 involved families in this village and 2 of them had 3 or 4 affected members. In this area, which is geographically close to the equator, all 40 cases [100%] had photodermatosis and 36/40 cases [90%] had bacterial skin infections during summer. In addition, they had limited outdoor exposure during this season. These complications also caused occupational, social and educational limitations 9 months a year. Eye problems were present in all 40 cases; however, all 40 cases were malignancy free. Oculocutaneous albinism is challenging not only because of its management but also because of its social and financial impacts. The current trend of consanguineous marriages, prevalent in this village, puts further emphasis on the role and the importance of marriage counseling in such situations