ABSTRACT
Aims: Hepatoid carcinoma is a rare tumor that mimics the morphologic and immunohistochemical features of hepatocellular carcinoma. An exceptional occurrence in adrenal gland has been recorded in the literature. The aim of this work is to study the morphologic immunohistochemical differential diagnosis and prognosis of adrenal hepatoid carcinoma. Presentation of Case: We present a rare case of hepatoid carcinoma of left adrenal gland in 70- year-old-men. Histologically, the adrenal mass was composed of cells with enlarged nuclei, proeminent nucleoli and eosinophilic cytoplasm, arranged in a pseudoglandular and thick trabecular pattern with bile plugs, which resembled hepatocellular carcinoma. The main differential diagnosis was adrenal metastasis from hepatocellular carcinoma. The adrenal gland origin of the hepatoid carcinoma was verified by the absence of liver mass on clinical and imagery grounds. Conclusion: We present the first case of adrenal hepatoid carcinoma in Tunisia. The main differential diagnosis was adrenal metastasis from hepatocellular carcinoma, which was eliminated by the absence of liver tumor.