Concurrence of Sweet's Syndrome, Pathergy Phenomenon and Erythema Nodosum-like Lesions

We report the case of a 54-year-old woman with concurrent Sweet's syndrome, pathergy phenomenon and eythema nodosum-like lesions associated with suppurative tonsillitis. Tender, violaceous and highly edematous papules and plaques were detected on the forearms and legs, some of which were pseudovesicular. Similar edematous papules were detected on the dorsum of the hands at the sites of intravenous injection. Biopsies of a plaque on the forearm and a papule at the site of intravenous injection confirmed the presence of Sweet's syndrome. Multiple, tender, violet-red, subcutaneous erythematous nodules were revealed on the legs. A biopsy taken from a nodule on the leg revealed septal panniculitis. To our knowledge, no patient with concurrent Sweet's syndrome, pathergy phenomenon, and erythema nodosum-lesions had been reported yet in previous literature.

Study of 2010-2012 western medicine comprehensive test in postgraduate entrance examina-tion based on multivariate generalizability theory / 中华医学教育探索杂志

Objective To systematically evaluate the overall reliability,test paper structure and rationality proportional distribution of the secondary discipline of western medicine comprehensive test papers from 2010 to 2012 to provide references for future improvement to the syllabus and test quality. Methods Data of 15 765 candidates from 2010 to 2012 were extracted and statistical analy-sis was performed to do generalized research and decision-making research from discipline factors and question type factors. Results ①Based on the discipline factor analysis,variance components of ba-sic disciplines were relatively high ,global score relative error was very small and the generalizability coefficient was above 0.930. ②Based on the question type factor analysis,variance components in X-type questions and A1-type questions were relatively high, global score relative error was very small and the generalizability coefficient was above 0.930. Conclusions ①From the discipline content, the accuracy of various disciplines is high;contribution of basic disciplines is relatively higher than that of clinical disciplines;further improving the discrimination of questions can help to improve measure-ment accuracy. ②From the question design,question measurement error is small,accuracy is high,and the question distribution is appropriate;scale of A3 type questions can be further improved.

Content of gentiopicroside and loganic acid in Radix gentianae and their fingerprints / 药学学报

To develop a HPLC-DAD-ESI-TOF/MS analysis method for the determination of gentiopicroside and loganic acid in Radix gentianae samples and for the research of their fingerprints. The samples were extracted using ASE for 10 min under 100 degrees C and 9.65 MPa, and divided into water phase and chloroform phase and analyzed them with HPLC-DAD-ESI-TOF/MS method respectively. Based on this method, the HPLC fingerprints of Radix gentianae were established. Comparing the spectrogram and mass spectrum of the chromatogram peak with the reference value, three compounds in water phase were identified as gentiopicroside, asafetida acid and loganic acid. There is no report of the compounds in chloroform phase. The content of gentiopicroside and loganic acid in samples of different groups were determined, separately. The fingerprints were compared by the software of the similarity evaluation system for chromatographic fingerprint. The water phase fingerprint congruence coefficients of samples from six different areas were above 0.90, however, the chloroform phase fingerprint congruence coefficients were within 0.62 -0.99. This method can be used for determination of potent component in Radix gentianae and its quality control. Radix gentianae from different producing areas have the largest diversities, and the diversities embodied in the content of chloroform phase compounds.