ABSTRACT
Objective To study the effect of alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy.Methods From January 2014 to June 2016,120 patients with type 2 diabetic peripheral neuropathy in the First People's Hospital of Baiyin were randomly divided into two groups according to the random number table method.64 patients of the observation group were given the treatment of alprostadil,epalrestat combined with methylcobalamin.56 patients of the control group were given the treatment of alprostadil and methylcobalamin.And the two groups were treated for 4 weeks.The blood glucose,clinical symptoms,adverse reaction,nerve conduction velocity index were compared between the two groups before and after treatment.Results The fasting blood glucose and 2-hour postprandial blood glucose of the two groups after treatment were significantly decreased (t =18.20,17.61,15.75,23.69,all P ＜ 0.05),and the conduction velocity of the common peroneal nerve,the median nerve and the ulnar nerve in the observation group were significantly higher than those in the control group (t =1.989,2.638,3.026,2.187,2.619,1.997,all P ＜ 0.05).The total effective rate of the observation group was significantly higher than that of the control group(95.3％ vs.82.1％,x2 =4.54,P ＜0.05).There were no statistically significant differences in the blood glucose and the incidence rate of adverse reactions between the two groups (t =0.267,0.176,0.695,0.658,x2 =1.356,all P ＞ 0.05).Conclusion Alprostadil combined with epalrestat and methylcobalamin in the treatment of type 2 diabetic peripheral neuropathy has good effect.
ABSTRACT
Objective To observe the clinical efficacy of moxibustion plus Cang Gui Tan Xue (dark turtle seeking hole) needling method in treating cervical spondylosis of nerve root type. Method Sixty patients with cervical spondylosis of nerve root type were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by moxibustion plus Cang Gui Tan Xue needling method, and the control group was by simple needling method. The symptom and sign score was observed before and after 2-course treatment, and the clinical efficacy was compared. Result The total effective rate was 90.0%in the treatment group versus 83.3%in the control group, and the difference was statistically significant (P<0.05). After intervention, the symptom and sign scores were significantly changed in both groups (P<0.05). There was a significant difference in comparing the symptom and sign score between the two groups after intervention (P<0.05). Conclusion Moxibustion plus Cang Gui Tan Xue needling method is effective in treating cervical spondylosis of nerve root type.