ABSTRACT
Icariin (ICA) is one of the main active ingredient,isolated from Herba epimedii of Chinese medicine plant.It is generally used to treat osteoporosis,kidney dificiency and others.In this paper,the pharmacological effects of Icariin were summarized in the fields of anti-osteoporosis,antitumor,immunomodulation,improving reproduction,lowering blood sugar and protecting nervous system in the literatures.This paper provides a basic understanding of icariin for future studies.
ABSTRACT
The rhizome of Trillium Trillium tschonoskii Maxim. coming from liliaceous has the functions of tranquilizing and tranquilizing blood and detoxifying and detoxifying, which is used to treat the diseases of hypertension, neurasthenia, dizziness, headache, injury, trauma and hemorrhage. This paper summarized the pharmacological studies. We found that Trillium tschonoskii Maxim can be used for anti-cancer, anti-inflammatory analgesic, immune regulation, liver protection, improvement of cerebral ischemia, heart function, anti-oxidation, anti-aging effect, the pharmacological effects on the central nervous system and so on. This paper provides a reference for the research development and clinical application of Trillium tschonoskii Maxim.
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Objective To investigate the correlation and clinical significance between serum uric acid (SUA) levels and insulin resistance in type 2 diabetes(T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods There were 54 T2DM patients with NAFLD in combined group ,50 cases in simple T2DM group and 37 cases in healthy group.The clinical parameters,SUA and insulin resistance (IR) levels were determined and compared among the three groups.The correlations among NAFLD,SUA levels and IR were analyzed.Results The SUA levels and IR index ( HOMA-IR) of the combined group were higher than those of the other two groups ( SUA:F=9.77,P=0.00;IR:H=122.13,P=0.00).The studies showed that NAFLD was positively correlated with SUA , TG,HOMA-IR(r =0.323,P =0.00;r =0.294,P =0.00;r =0.331,P=0.00).Logistic regression analysis revealed that IR,SUA and TG were the risk factors for T2DM with NAFLD(B=0.852,0.012,0.707).Conclusion The increase of SUA is independent risk factor for T 2DM with NAFLD,so to control SUA and improve insulin sensitivity can help to prevent the development of T 2DM with NAFLD.
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Objective To compare the short-term effects between interventional arterial embolization and iodine-131 therapy in treating Graves'disease.Methods A total of 84 patients with Graves'disease (GD),confirmed by clinical data and laboratory tests,were divided into two groups:interventional group(n=42)receiving arterial embolization and iodine-131 group(n=42)receiving iodine-131 therapy.Before and after the treatment thyroid angiography and SPECT/CT imaging were performed to determine the shape and size of the thyroid,and radioimmunoassay method was used to measure serum levels of FT3,VF4,TSH and TRAb at 3.6 and 12 months after the therapy.The results were compared and statistically analyzed.The occurrence of complications was observed. Results No statistically significant difference in short-term therapeutic effects was found between interventional group and iodine-131 group.The occurrence of early severe complication was much higher in interventional group than that in iodine-131 group,while the occurrence of hypothyroidism was obviously higher in iodine-131 group than that in interventionai group.Conclusion Both interventional embolization and iodine-131 therapy have reliable effect for the treatment of Graves'disease.Iodine-131 therapy may be used in patients who plan to receive initial treatment or in patients who failed to effectively respond to other kinds of therapies,while interventional embolization may be employed in patients who are not able to receive surgery or in patients who have failed to respond to antithyroid drug treatment,or in patients whose iodine-131 intake rate is too low to undergo iodine-131 therapy,especially in patients with refractory and intractable hyperthyroidism. Interventional embolization can be regarded as an alternative treatment for Graves'disease.