ABSTRACT
Ameloblastoma is a benign, locally aggressive neoplasm that constitutes about 1–3% of the tumors of the jaw. Wide surgical excision with adequate safe margin is the most common treatment of choice. The study aimed to manage cases with unicystic ameloblastoma while preserving the continuity of the mandible (without resection). This article presents a series of cases ranging from 18 to 40 years old patients of both sexes with unicystic ameloblastoma, especially in the mandible showing more male predilection than female. All the cases presented in this article were treated by enucleation and curettage. None of the patients presented post?operative paresthesia. None of the cases went in for resection. Post?operative recovery was uneventful in all the patients. All the patients were followed up for a period of 3.5–5 years. None of the cases reported recurrence at the date of publication.
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Introduction: Cancer outcomes continue to improve dueto earlier detection and newer targeted therapies, withanthracycline chemotherapy playing a major role in themodern era of cancer treatment. Anthracyclines are listedamong the World Health Organization (WHO) model list ofessential medicines. Study aimed to evaluate the incidenceof the subclinical cardiac dysfunction associated withAnthracyclines based regimen in patients with breast cancerat a tertiary care center.Material and Methods: 110 patients with breast cancerpatients receiving Anthracycline-based chemo regimenwere enrolled in the study. All enrolled patients with breastcancer underwent baseline cardiac assessment and periodicmonitoring of cardiac function by noninvasive diagnostictoolsResults: The incidence of Anthracycline-induced cardiacabnormalities in this study was 38.1%. The incidence ofsubclinical cardiac dysfunction was more than overt cardiacdysfunction. The overt cardiac abnormality was observed in13.6% and subclinical cardiac dysfunction was observed in24.5% of our patients.Conclusion: Early identification of patients with subclinicalcardiac dysfunction aids in early intervention and preventionof further deterioration of cardiac dysfunction.
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Background. Tobacco has long been identified as one of the most hazardous risk factors detrimental to health. To plan and implement anti-tobacco activities in any community, it is necessary to understand the risk it poses in that setting. We assessed the risk of mortality associated with tobacco use in a rural community of Kerala. Methods. This cohort study (PROLIFE) was done in Varkkala, a rural development block of Thiruvananthapuram district of Kerala. Adults aged 20 years and above were included. Age-adjusted mortality rates were computed for both users and non-users of tobacco. The risk of mortality was plotted using Kaplan–Meier curves. Cox regression was used to compute the age-adjusted hazard ratio of mortality among tobacco users. Results. More than one-fourth of the study population used tobacco. The age-adjusted mortality rates were higher among tobacco users. The major causes of death among both users and non-users of tobacco were similar. The incidence proportion of death among all causes of death was higher for tobacco users. The hazard of mortality was significantly more among tobacco users, with the age-adjusted hazard ratio being 1.225 (1.140–1.315). Conclusion. The mortality risk due to tobacco use is high irrespective of the cause of death.
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Adult , Aged , Cause of Death , Cohort Studies , Female , Humans , India , Male , Middle Aged , Proportional Hazards Models , Risk , Rural Population , Smoking/mortalityABSTRACT
Objective. To evaluate the efficacy of Fine Needle Aspiration Cytology (FNAC) to diagnose Tuberculous (TB) lymphadenitis with compare to excision biopsy and to correlate TB lymphadenitis with clinical, cytological, radiological and mantoux test features. Methods. This was a prospective correlational study. FNAC was done by a pediatrician for 135 children with persisting lymphadenitis after two weeks of antibiotic therapy in the period of January 2005 to June 2006 and compared with excision biopsy in a tertiary care hospital. Results. Forty Six cases (34.07%) were TB lymphadenitis diagnosed by FNAC. Excision biopsy and cytological correlation was done in 100 cases. Sensitivity, specificity and diagnostic accuracy for TB lymphadenitis were found to be 98%, 100% and 99% respectively. Positive and negative predictive values were 100 and 98 respectively. Large (>2cm) (86.9%), multiple (52.1%), matted (47.8%), posterior cervical and submandibular group nodes with history of contact (P=0.0016), positive mantoux test (P=0.0001) and Grade III and IV Protein Energy Malnutrition (PEM) (P=0.0041) were significantly seen in TB lymphadenitis. Ziehl Neelson staining for Acid Fast Bacilli (AFB) was positive in 32.5% cases of TB Lymphadenitis. Conclusion. Pediatrician himself can do FNAC which is an excellent first line method to diagnose TB lymphadenitis and it has equal accuracy to excision biopsy.