ABSTRACT
The aim of the current study is to evaluate the effect of ethanolic seed extract of Caesalpinia bonduella (ESECB)on altered hormonal levels in mifebristone-induced polycystic ovarian syndrome (PCOS) female rats. PCOS wasinduced in female rats by a daily administration of mifepristone (4 mg/kg b.w.) for 8 days which was confirmed bythe persistent estrous cycle. Once PCOS was induced, the rats were treated with ESECB 200 and 400 mg/kg b.w.p.o. for 28 days, and the hormonal parameters were analyzed. Metformin was used as a standard drug. A significantincrease (p < 0.01) in the luteinizing hormone, Prolactin, insulin, testosterone, estrone, and estradiol levels anddecrease in follicle stimulating hormone and progesterone hormone levels in the PCOS rats were observed, whichwere normalized in the ESECB drug-treated animals. Among the two concentrations, 400 mg/kg b.w of ESECB drugtreatment showed significant effect in correcting this hormonal imbalance. Its effect was comparable to the positivecontrol used in the present study. It can be concluded that the ESECB can be used as a potential ovulation inducerin the treatment of PCOS