Predictors of outcome in patients with spontaneous intracereberal hemorrhage admitted to Liaquat University Hospital

To study the frequency of mortality and evaluate the influence of various prognostic factors such as Glasgow Coma Scale [GCS] Score, volume of hematoma and age on the outcome of the patient admitted with intracereberal hemorrhage. This descriptive case series study was conducted at Liaquat University of Medical aHealth Sciences hospital from July 2006 to March 2008. It included 399 consecutive patients with a diagnosis of SICH wthin 24 hours of their first stroke onset. Patients excluded from study were with hemorrhage secondary to brain tumors, to trauma, to hemorrhagic transformation of cerebral infarct and with previous history of hemorrhagic stroke. The patients' data was collected in a well designed Proforma. The volume of hematoma was calculated according to ABC/2 formula. Quantitative variables were described as mean with +/- SD. While qualitative variables were described as frequency and percentages. Age, GCS score and volume of hematoma compared to the outcome of the patients by receiver operating characteristics [ROC]. The level of Significance was <0.05. This study included 399 patients of which 261 [65.4%] were male and 138 [34.6%] were female. The number of patients <65 years were 222 [55.6] whereas 177 [44.4%] patients were >65 years old. The number of patients who died during hospitalization were 122 [30.6%] and 277 [69.4%] patients remained alive. AUR comparing the volume of hematoma is 0.707 [p=0.001], GCS on admission 0.815 [p=0.001] and age had 0.552 [p=095]. This study showed elderly patients with decreased level of consciousness and hemorrhage > 60 ml have the worst outcome

Frequency of steatosis and its relation with the grade of fibrosis in patients with hepatitis C

To study the frequency of steatosis and observe the relation between steatosis and grade of fibrosis in patients with hepatitis C. This descriptive case series study was undertaken at liaquat University of Medical and Health Sciences hospital from July 2005 to November 2007. It included 158 PCR-positive hepatitis C cases with genotype 3. Patients demographic data was enrolled in welt designed proforma BMI was calculated and history of diabetes metlitus was obtained. Liver biopsy was done after written consent and was sent for grading of fibrosis and steatosis. T-test was applied for continuous variables whereas stage of fibrosis was compared with grade of steatosis, BMI and age by chi-square test. 0.05 was made a level of Significance. This study included 158 patients out of which 109 [69%] were male and 49[31%] were female. The mean age of the patient was 36.8 +/- 9.8.The BMI was <25 in 86[54.4%] whereas BMI 25-30 was present inS3 [33.5%] and BMI >30 in 19 [12%] of cases. The steatosis was found in 71[45%] of cases. Mild [<30% of hepatocytes involved] 33[21%], moderate [30-60% hepatocytes involved] in 26 [16.5%] and severe [>60% hepatocytes involved] steatosis in 12[7.5%] cases. A strong correlation between steatosis score and fibrosis stage was observed in our study [P= < 0.001] whereas no relationship was observed between BMI [P = 0.67] or age [P =0.39] with stage of steatosis. This study showed that increased steatosis is associated with worsening fibrosis suggesting a possible role for steatosis in the acceleration of Liver disease in HCV Patients and efforts to control steatosis may therefore have an important role in halting HCV liver disease progression