Effect of Minimally invasive drainage of hematoma on hypertensive cerebral hemorrhage in patients with neurological functional recovery / 中国基层医药

Objective To evaluate the efficacy of minimally invasive drairage of hematoma in treatment of hypertensive cerebral hemorrhage. Methods 60 patients with hypertensive cerebral hemorrhage were randomly divided into two groups,including the observation group of minimally invasive hematoma drainage, the control group 30 cases, a small bone window intracranial hematoma,observe and compare the two groups of hypertensive cerebral hemorrhage the neurological function recovery. Results The operative time was significantly shorter than that used in the control group. Postoperative mortality, the difference was significant (P <rate,the difference was significant( P < 0.05 ). Hematoma drainage time of the observation group was significantly shorter than that in the control group,two groups of neural function in SSS score comparison showed that 21 daysafter treatment ,SSS score in observation group was significantly higher in the observation group than the control group. Observation group MRS scores and BI scores were significantly improved, and the ADL rating was significantly beffer than the control group( P < 0.05 or P < 0.01 ). Conclusion The minimally invasive hematoma drainage in the treatment of hypertensive cerebral hemorrhage with a short time, could significantly promote the recovery of neurological function in patients and reduce patient complications and mortality ,but also be neficial to activities of daily living (ADL) recovery.

Influence of mild hypothermia therapy on expression of heat shock proteins in lymphocyte in patients with severe craniacerebral injury / 临床神经病学杂志

Objective To explore the influence of mild hypothermia therapy on expression of heat shock protein(HSP)60,HSP70,HSP90 in lymphocyte in patients with severe craniacerebral injury.Methods 23 patients with severe craniacerebral injury were randomly divided into the mild hypothermia group (12 cases) and the normothermia group(11 cases).At the base of routine therapy,the mild hypothermia group received mild hypothermia therapy by the temperature control blanket to keep the body temperature among 32～34℃ for 4～6 d.The expression of HSP60,HSP70,HSP90 in lymphocyte were measured by Western Blot at the 1st d,4th d and 8th d after treatment.The infection incidence was observed at 7 d after treatment.And the expression of HSPs in lymphocyte at 32℃ and 37℃ in normal control group were measured respectively.Results Compared with normothermia group,the expression of HSP60 in mild hypothermia group was significantly lower at each time point(all P