ABSTRACT
Accumulation of metal in fish flesh is increasing because of heavy metal pollution in rivers of India, which poses significant threat to the consumers’ health. Here, we studied the concentrations of heavy metals [cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb) and zinc (Zn)] in the muscle tissues of Banded or Striped gourami, Trichogaster fasciata Bloch & Schneider collected from the river Ganges and its tributaries in order to assess the risk the consumers are put to. The order of metal accumulation (Zn>Pb>Cu>Cr>Cd) was found to be the same in both the fish muscle and the water samples. Significant values of correlation of coefficient (R = 0.9184-0.9612) of length-weight relationship and mean condition factor ranging between 1.876-2.420 g/cm3 of different populations of the fish were recorded. All metal concentration was negatively correlated with the fish size and condition factor except Zn in Ghaghara and Yamuna (P <0.05) and Pb in the Ganges (P <0.05) and Yamuna (P <0.001). Estimated daily intakes by the fish-eating inhabitants were lower than the maximum tolerable daily intake value except for that of Zn. The target hazard quotient and health index showed that intake of these heavy metals was quite safe by the fish consuming local populations including both the male and females. This study could be used as an essential piece of information for the management purposes of river Ganga to prevent heavy metal pollution and risk associated with it.
ABSTRACT
Rational drug use study is important for the patient care, and also act as a measure of the quality of care which is provided to patients, this study was conductedin the outdoor departments of 20 selected health facilities out of total 36 facilities of province Punjab, Pakistan by applying the core indicators of WHO.Average number of drug prescribed was 3.2 per prescription, percentage of generic drugs was 29.7%, percentage of antibiotic prescribed, injection prescribed, and percentage of drugs from NEDL were 64%, 0%, 96.5% respectively while ciprofloxacin was the most commonly used antibiotic. Average consultation time was 2.58 minutes; average dispensing time 88.5 seconds, percentage of drug actually dispensed was 82.9%, percentage of drug adequately labeled 96.9%, percentage knowledge of correct dosage 24%. Availability of NEDL or formulary was 90%,percentage of availability of key drugs in stock was 64.3%.Overall condition of rational use of medicines was not satisfactory in hospitals; this study will promote the rational use of medicines and good clinical pharmacy practice in hospitals of province Punjab, Pakistan by identifying the problems in rational use of drugs.