ABSTRACT
Introduction: The ureteral stent placement has become a partof urological clinical practice to relieve ureteral obstructioncaused by variety of urological condition since 1967. Studyaimed to access the role of anticholinergic (Tolterodine),uroselective α 1D/1A blocker (Naftopidil) alone and incombination to evaluate DJ stent related discomfort or pain,lower urinary tract symptoms and impact on quality of life.Materials and methods: This was a randomized double blindplacebo controlled comparative prospective clinical studyconducted between May 2013 to February 2015 to access therole of anticholinergic (Tolterodine), uroselective α 1D/1Ablocker (Naftopidil) alone and in combination to evaluate DJstent related discomfort or pain, lower urinary tract symptomsand impact on quality of life.Result: Total of 280 patients were enrolled for the study. 33patients were excluded. We found Naftopidil and combinationto be significanty better for pain score, combination beingmore effective for storage symptoms, voiding symptoms andquality of life scores.Conclusion: Combination of Tolterodine and Naftopidil canbe recommended for relief of stent related discomfort andurinary symptoms.
ABSTRACT
Hyaluronic acid (HA) is a natural-non sulphated high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. The use of HA in the treatment of inflammatory process is established in medical areas such as orthopedics, dermatology and ophthalmology. In the field of dentistry, hyaluronate has shown anti-inflammatory, antiedematous and anti-bacterial effects for the treatment of gingivitis and periodontitis. Due to its potential role in modulation of wound healing, its administration to periodontal wound sites could achieve comparable beneficial effects in periodontal tissue regeneration and periodontal disease treatment.